Real-life data on the comorbidities in spondyloarthritis from our multicenter nationwide registry: BioStar
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Date
2023
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Abstract
Objectives: Considering that the comorbid situations during the management of Spondyloarthritis (SpA) have been underlined in several recommendations, the main objective of this study was to evaluate the comorbid conditions of Turkish patients with SpA. Patients and methods: This cross-sectional observational study was conducted with 1,242 SpA patients (844 males, 398 females; mean age: 43.9±11.0 years; range, 19 to 81 years) diagnosed according to the modified New York criteria for ankylosing spondylitis or the Assessment of SpondyloArthritis International Society (ASAS) criteria. The patient data were collected from the Biologic and targeted Synthetic antirheumatic drugs Registry (BioStar) between February 1, 2019, and December 29, 2020. Clinical and demographic data, including, age, sex, disease duration, body mass index (BMI), pain, patient’s global assessment, physician’s global assessment, Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity Score, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, and Maastricht Enthesitis Score, were recorded. Comorbid conditions were recorded by filling out a questionnaire according to the clinical history or medical records. Charlson Comorbidity Index and Rheumatic Disease Comorbidity Index scores were calculated from the gathered comorbidity information. Results: Nine hundred thirteen patients had radiographic axial SpA, 153 had nonradiographic axial SpA, and 176 had peripheral SpA. The most common comorbidities were hypertension (HT) (n=167, 13.4%), diabetes mellitus (DM) (n=83, 6.7%), thyroid disorders (n=64, 5.6%), and depression (n=61, 4.9%). The comorbidities and the calculated comorbidity indices were significantly higher in females, in those with a BMI >25 kg/m2, and those over 60 years of age. No relationship was found between smoking and alcohol use and comorbidities. A significantly higher prevalence of HT and DM in peripheral SpA patients and a lower prevalence of thyroid disorders in radiographic axial SpA patients were observed. Conclusion: The most commonly reported comorbidities were HT, DM, thyroid disorders, and depression in SpA patients according to the BioStar database. The frequency of comorbidities and composite comorbidity scores were higher among females, older (>60 years) patients, and overweight (BMI >25 kg/m2) patients. © 2023 Turkish League Against Rheumatism. All rights reserved.
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acute heart infarction , adult , aged , alcohol consumption , Ankylosing Spondylitis Disease Activity Score , Article , Bath ankylosing spondylitis disease activity index , Bath ankylosing spondylitis functional index , Biologic and targeted Synthetic antirheumatic drugs Registry , body mass , body weight , cardiovascular disease , cerebrovascular disease , Charlson Comorbidity Index , chronic lung disease , comorbidity , congestive heart failure , cross-sectional study , depression , diabetes mellitus , diabetic complication , disease assessment , disease duration , disease registry , enthesitis , erythrocyte sedimentation rate , female , gastrointestinal hemorrhage , hemiparesis , human , hypertension , kidney disease , Kruskal Wallis test , Maastricht Ankylosing Spondylitis Enthesitis Score , major clinical study , male , malignant neoplasm , multicenter study , musculoskeletal disease assessment , non-radiographic axial spondyloarthritis , obesity , observational study , pain , pain assessment , patient global assessment , pelvis radiography , peptic ulcer , physician , physician global assessment , prevalence , questionnaire , Rheumatic Disease Comorbidity Index , smoking , spondylarthritis , thyroid disease , Turk (people)