Relationship between duodenal histopathology and strong positive tissue transglutaminase antibodies in children with celiac disease; [Çölyak hastası çocuklarda duodenal histopatoloji ve güçlü pozitif doku transglutaminaz antikorları arasındaki ilişki]

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dc.contributor.authorDoğan G.
dc.contributor.authorAyhan S.
dc.contributor.authorYılmaz B.
dc.contributor.authorAppak Y.Ç.
dc.contributor.authorDündar P.E.
dc.contributor.authorEcemiş T.
dc.contributor.authorÜnal F.
dc.contributor.authorKasırga E.
dc.date.accessioned2024-07-22T08:12:43Z
dc.date.available2024-07-22T08:12:43Z
dc.date.issued2015
dc.description.abstractIntroduction: In celiac disease (CD) strong positive tissue transglutaminase antibody (TTGA) levels (≥100 U/A) have been shown to almost always indicate villous atrophy. The aim of this study is to determine the sufficiency of ≥100 U/A Ig A type TTGA levels for diagnosis of CD. Materials and Methods: Results from duodenum biopsy performed due to positive TTGA in 197 children were retrospectively examined. IgA TTGA levels had a positive value of >18 U/A. Increases of 5 times or more than this threshold value (≥100 U/A) are accepted as strong positivity. CD diagnosis was made according to ESPGHAN criteria. A modified Marsh stage ≥2 was accepted as significant for CD. Results: Of the cases, 129 were female (65.5%) and 68 were male (34.5%). Duodenum histopathology was compatible with Marsh 0 for 1 case (0.5%), Marsh 2 for 17 cases (8.6%), Marsh 3a for 41 (20.8%), Marsh 3b for 81 (41.4%) and Marsh 3c for 57 (28.9%). The TTGA levels of 64 of the 197 cases (32.5%) were ≥100 U/A. In cases with strong positivity for TTGA the duodenum histology was compatible with Marsh 3 (villous atrophy) for 63 and Marsh 0 (normal histology) for 1 case (type 1 diabetic and asymptomatic for CD). For Marsh 3c TTGA levels ≥100 U/A had a sensitivity of 85.96% (95% CI: 74.2-93.7%), specificity of 89.29% (95% CI: 82.9-93.8%), positive predictive value of 76.56% (95% CI: 64.3-86.2%) and negative predictive value of 93.9% (95% CI: 88.4- 97.3%). Conclusions: This study showed that positive IgA TTGA levels (≥100 U/A) were almost always accompanied by Marsh 3 duodenal histopathological changes. Diagnosis of CD without biopsy may miss certain accompanying diseases, however in some cases with advanced examinations CD may be diagnosed by pediatric gastroenterology specialists without endoscopy. © The Journal of Current Pediatrics, published by Galenos Publishing.
dc.identifier.DOI-ID10.4274/jcp.81994
dc.identifier.issn13049054
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16161
dc.language.isoTurkish
dc.publisherGalenos Yayincilik,
dc.rightsAll Open Access; Green Open Access
dc.subjectimmunoglobulin A
dc.subjectprotein glutamine gamma glutamyltransferase antibody
dc.subjectArticle
dc.subjectceliac disease
dc.subjectchild
dc.subjectdiagnostic test accuracy study
dc.subjectdisease classification
dc.subjectduodenum biopsy
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectinsulin dependent diabetes mellitus
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpredictive value
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.titleRelationship between duodenal histopathology and strong positive tissue transglutaminase antibodies in children with celiac disease; [Çölyak hastası çocuklarda duodenal histopatoloji ve güçlü pozitif doku transglutaminaz antikorları arasındaki ilişki]
dc.typeArticle

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