Lack of association between leptin levels and leptin gene polymorphism in obese women

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dc.contributor.authorOkudan N.
dc.contributor.authorGökbel H.
dc.contributor.authorAcar H.
dc.contributor.authorUzunoʇlu S.
dc.contributor.authorBelviranli M.
dc.date.accessioned2024-07-22T08:15:35Z
dc.date.available2024-07-22T08:15:35Z
dc.date.issued2014
dc.description.abstractThe aim of the present study was to evaluate the relationship between oligopolymorphism in the 25th codon of leptin gene and obesity. Eighty-seven obese women and 75 healthy women were constituted obese and control groups. Body fat percent, fat mass and lean body mass were determined by bioimpedance meter and leptin levels were determined. The presence of 25th codon oligopolymorphism in the leptin gene was done by PCR-RFLP technique. Mean leptin levels were 38.5±22.0ng/ml, and 147.9±44.8ng/ml in the control and obese groups, respectively. The correlations of serum leptin level to body fat percentage and fat mass in the control group were significant. The correlations in the obese group were not significant. This data implies that the difference of leptin levels between control and obese groups are more likely to be associated with alterations in the leptin gene other than 25th codon or alterations in the leptin receptor gene. © 2014 Informa UK Ltd. All rights reserved.
dc.identifier.DOI-ID10.3109/13813455.2014.946933
dc.identifier.issn13813455
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16747
dc.language.isoEnglish
dc.publisherInforma Healthcare
dc.subjectAdipose Tissue
dc.subjectAdult
dc.subjectBody Composition
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHumans
dc.subjectLeptin
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Genetic
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectleptin
dc.subjectadipose tissue
dc.subjectadult
dc.subjectblood
dc.subjectbody composition
dc.subjectbody mass
dc.subjectcase control study
dc.subjectcomparative study
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgenetic polymorphism
dc.subjectgenetics
dc.subjecthuman
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.titleLack of association between leptin levels and leptin gene polymorphism in obese women
dc.typeArticle

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