Cardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children

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dc.contributor.authorYilmazer M.M.
dc.contributor.authorTavli V.
dc.contributor.authorCarti Ö.U.
dc.contributor.authorMese T.
dc.contributor.authorGüven B.
dc.contributor.authorAydIn B.
dc.contributor.authorDevrim I.
dc.contributor.authorTavlI T.
dc.date.accessioned2024-07-22T08:20:43Z
dc.date.available2024-07-22T08:20:43Z
dc.date.issued2010
dc.description.abstractObesity is associated with a number of risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension, and early atherosclerosis. Evidence indicates that atherosclerosis begins in childhood and progresses over decades. In this work, we examined the relationship between cardiovascular risk factors and ultrasonographic signs of subclinical atherosclerosis in 77 obese children and adolescents compared to 40 non-obese healthy peers. Carotis intima media thickness (cIMT), carotid artery compliance (CAC), brachial artery flow-mediated dilatation (FMD), and established cardiovascular risk factors were studied. In the obese patients, cIMT was significantly increased (0.57 mm vs 0.45 mm, p<0.001) whereas CAC (1.84% vs 3.29%, p<0.001) and FMD (9.67 % vs 14.81%, p<0.001) were significantly decreased. In multiple linear regression analysis, a relation was observed between cIMT, CAC, brachial FMD on one hand, and body mass index (BMI) on the other. Among the lipid anomalies, only hypertriglyceridemia was found to be positively correlated with cIMT. Additionally, we found a significant association between waist circumference (WC) and FMD. These findings indicate that obesity in children is associated with arterial wall alterations and endothelial dysfunction. In hyperlipidemic situations, only hypertriglyceridemia was found to be positively correlated with cIMT. This finding has consistently indicated TG to be a risk factor for the development of atherosclerosis. To our knowledge this is the first study to determine the relation between FMD and WC, which is used as a parameter of obesity in childhood. © 2010 Springer-Verlag.
dc.identifier.DOI-ID10.1007/s00431-010-1216-5
dc.identifier.issn03406199
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18273
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAtherosclerosis
dc.subjectBiological Markers
dc.subjectBody Mass Index
dc.subjectBrachial Artery
dc.subjectCarotid Arteries
dc.subjectChi-Square Distribution
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertriglyceridemia
dc.subjectLinear Models
dc.subjectMale
dc.subjectObesity
dc.subjectReproducibility of Results
dc.subjectRisk Factors
dc.subjectStatistics, Nonparametric
dc.subjectTunica Intima
dc.subjectTurkey
dc.subjectadolescent
dc.subjectarterial wall thickness
dc.subjectartery compliance
dc.subjectartery dilatation
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectbody mass
dc.subjectbrachial artery
dc.subjectcardiovascular risk
dc.subjectcarotid artery
dc.subjectchild
dc.subjectcontrolled study
dc.subjectechography
dc.subjectendothelial dysfunction
dc.subjectfemale
dc.subjecthuman
dc.subjecthypertriglyceridemia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple linear regression analysis
dc.subjectobesity
dc.subjectpriority journal
dc.subjectschool child
dc.subjectTurkey (republic)
dc.subjectwaist circumference
dc.titleCardiovascular risk factors and noninvasive assessment of arterial structure and function in obese Turkish children
dc.typeArticle

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