The effects of handgrip stress test on hemodynamic parameters before and after cilazapril treatment in patients with heart failure

Simple item page
dc.contributor.authorTavli T.
dc.contributor.authorGöçer H.
dc.date.accessioned2024-07-22T08:25:04Z
dc.date.available2024-07-22T08:25:04Z
dc.date.issued2003
dc.description.abstractObjective: To assess the effect of cilazapril treatment on several hemodynamic parameters during handgrip manuevers in patients with congestive heart failure. Cilazapril, an ACE inhibitor with high affinity, has been shown to be highly effective against a variety of vascular disorders. The effectiveness of isometric handgrip exercise on changes of cardiovascular hemodynamic parameters before and after cilazapril treatment in patients with congestive heart failure is unknown. Methods: The study population included 30 patients (16 male, 14 female) with mean age of 65±18 years. The effects of handgrip maneuver on hemodynamic parameters were studied by right heart catheterization and Doppler echocardiography. Results: Heart rate (HR) and mean arterial pressures (MAP) increased significantly after handgrip maneuver (from 95±6 beats/min to 101±12 beast/min; from 109±15 mm Hg to 118±19mm Hg, p<0.05 respectively). Pulmonary capillary wedge pressure (PCWP), pulmonary artery systolic (s) and diastolic (d) pressures (PAP), cardiac index (CI), right ventricular systolic and diastolic pressures (RVPs and RVPd), left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF) did not change after handgrip maneuvers (p<0.05). On the other hand, PAPs and PAPd, RVPs and RVPd, MAP and HR (p<0.05) decreased significantly during handgrip maneuvers after cilazapril treatment. However PCWP and CI, LVEF, RVEF did not change after treatment (p<0.05). Conclusion: Cardiovascular response to handgrip maneuver may be a marker of failure to respond to compensatory mechanisms. Cilazapril treatment was associated with significant improvement in hemodynamic parameters during handgrip stress test, the mechanisms of which are increased sympathetic and renin-angiotensin system activation, and altered vascular tonus.
dc.identifier.issn13028723
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20261
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectCilazapril
dc.subjectEchocardiography, Doppler
dc.subjectExercise Test
dc.subjectFemale
dc.subjectHand Strength
dc.subjectHeart Failure, Congestive
dc.subjectHemodynamic Processes
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectcilazapril
dc.subjectdigitalis
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectdiuretic agent
dc.subjectnitrate
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbinding affinity
dc.subjectblood vessel tone
dc.subjectcardiovascular parameters
dc.subjectcardiovascular response
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcongestive heart failure
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdiastolic blood pressure
dc.subjectdisease marker
dc.subjectDoppler echocardiography
dc.subjectdose response
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectexercise test
dc.subjectfemale
dc.subjecthand grip
dc.subjectheart catheterization
dc.subjectheart index
dc.subjectheart left ventricle ejection fraction
dc.subjectheart rate
dc.subjectheart right ventricle ejection fraction
dc.subjectheart right ventricle pressure
dc.subjecthemodynamic parameters
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectisometric exercise
dc.subjectlung artery pressure
dc.subjectlung capillary pressure
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectrenin angiotensin aldosterone system
dc.subjectside effect
dc.subjectsympathetic tone
dc.subjectsystolic blood pressure
dc.subjectvascular disease
dc.titleThe effects of handgrip stress test on hemodynamic parameters before and after cilazapril treatment in patients with heart failure
dc.typeArticle

Files

Collections

Scopus Koleksiyonu