Effectiveness of clonidine and fentanyl addition to bupivacaine in postoperative patient controlled epidural analgesia; [Wirksamkeit von clonidin und fentanyl als zusatz bei der postoperativen patientenkontrollierten epiduralanalgesie mit bupivacain]

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dc.contributor.authorTopcu I.
dc.contributor.authorLuleci N.
dc.contributor.authorTekin S.
dc.contributor.authorKefi A.
dc.contributor.authorErincler T.
dc.date.accessioned2024-07-22T08:23:47Z
dc.date.available2024-07-22T08:23:47Z
dc.date.issued2005
dc.description.abstractBackground and Objectives: The aim of this prospective randomized double-blinded study was to compare the analgesic and side-effects of bupivacaine in combination with clonidine or fentanyl during patient-controlled-epidural analgesia (PCEA) in the postoperative period after abdominal hysterectomy. Methods: 75 patients from 18 to 65 years of age with ASA status I - II were investigated. After preoperative epidural catheterization, the patients were operated in general anesthesia. After surgery, the patients were randomly allocated to 3 PCEA-groups: Group B 0.125% bupivacaine, Group F 0.125% bupivacaine plus 1 μg × ml-1 fentanyl, Group C 0.125% bupivacaine plus 0.75 μg × ml-1 clonidine (10 ml loading dose, 5 ml repetitive bolus dose, 10 min lockout time, 30 ml limit within 4h). During the following 24 hours, hemodynamic parameters, pain score using visual analog scale (VAS), total analgesic consumption, additional analgesic requirements, sedation, satisfaction, nausea scores and probable side-effects were evaluated. Results: Total analgesic consumption was not different between Group F and Group C, but lower than in Group B (p < 0.05). Additional analgesic use was not different between the groups. Group F and Group C had lower VAS-scores in 24 hours than Group B (p < 0.05). Hemodynamic and sedation scores of patients were not different. In Group C, incidence of nausea was lower and satisfaction of patients was higher (p < 0.05). Conclusions: Addition of clonidine or fentanyl to local anesthetics for PCEA can reduce the analgetic demand. Epidural clonidine can reduce postoperative nausea and is connected with higher patients' satisfaction. © Georg Thieme Verlag KG Stuttgart.
dc.identifier.DOI-ID10.1055/s-2005-870397
dc.identifier.issn09392661
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19673
dc.language.isoGerman
dc.subjectAdolescent
dc.subjectAdrenergic alpha-Agonists
dc.subjectAdult
dc.subjectAged
dc.subjectAnalgesia, Epidural
dc.subjectAnalgesia, Patient-Controlled
dc.subjectAnalgesics, Opioid
dc.subjectAnesthetics, Local
dc.subjectBupivacaine
dc.subjectClonidine
dc.subjectFemale
dc.subjectFentanyl
dc.subjectHemodynamic Processes
dc.subjectHumans
dc.subjectHysterectomy
dc.subjectMiddle Aged
dc.subjectPain Measurement
dc.subjectPain, Postoperative
dc.subjectanalgesic agent
dc.subjectbupivacaine
dc.subjectclonidine
dc.subjectfentanyl
dc.subjectlidocaine
dc.subjectthiopental
dc.subjectvecuronium
dc.subjectabdominal hysterectomy
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug use
dc.subjectepidural anesthesia
dc.subjectevaluation
dc.subjectfemale
dc.subjecthemodynamic monitoring
dc.subjecthuman
dc.subjectintravenous anesthesia
dc.subjectmajor clinical study
dc.subjectnausea
dc.subjectoutcomes research
dc.subjectpain assessment
dc.subjectpatient controlled analgesia
dc.subjectpatient satisfaction
dc.subjectpostoperative pain
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectsedation
dc.subjectvisual analog scale
dc.titleEffectiveness of clonidine and fentanyl addition to bupivacaine in postoperative patient controlled epidural analgesia; [Wirksamkeit von clonidin und fentanyl als zusatz bei der postoperativen patientenkontrollierten epiduralanalgesie mit bupivacain]
dc.typeArticle

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