Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia

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dc.contributor.authorAydın O.
dc.contributor.authorLysaker P.H.
dc.contributor.authorBalıkçı K.
dc.contributor.authorÜnal-Aydın P.
dc.contributor.authorEsen-Danacı A.
dc.date.accessioned2024-07-22T08:09:25Z
dc.date.available2024-07-22T08:09:25Z
dc.date.issued2018
dc.description.abstractMany with schizophrenia experiences deficits in social cognition, neurocognition and metacognition. Yet the biological mechanisms which may underpin these cognitive deficits are poorly understood. Two candidate causes of these deficits are disturbances in oxytocin (OT) and vasopressin (VP). To explore this we assessed plasma OT and VP in 34 schizophrenia patients and 31 healthy controls. We also concurrently assessed social cognition using the Reading the Mind from the Eyes test, neurocognition using the Wisconsin Card Sorting Test and metacognition using the Metacognitive Assessment Scale-Abbreviated. Group comparisons revealed lower plasma OT levels in the schizophrenia group. Plasma VP levels did not differ between groups. Correlations revealed that lower levels of OT were associated with poorer levels of metacognitive functioning in the schizophrenia group but not poorer social cognition or neurocognition. In a stepwise multiple regression, plasma OT level, neurocognition and social cognition contributed uniquely to the prediction of metacognition in the schizophrenia group. Results may suggest that disturbance in OT is linked with deficits in metacognition and may interact with other forms of cognitive deficits, interfering with the person's abilities to form a complex and integrated sense of self and others. © 2018 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.psychres.2018.03.048
dc.identifier.issn01651781
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14813
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectCognition
dc.subjectCognition Disorders
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMetacognition
dc.subjectNeuropsychological Tests
dc.subjectOxytocin
dc.subjectSchizophrenia
dc.subjectSchizophrenic Psychology
dc.subjectSocial Behavior
dc.subjectSocial Perception
dc.subjectVasopressins
dc.subjectYoung Adult
dc.subjectoxytocin
dc.subjectvasopressin
dc.subjectoxytocin
dc.subjectvasopressin derivative
dc.subjectadult
dc.subjectArticle
dc.subjectblood sampling
dc.subjectclinical article
dc.subjectclinical assessment
dc.subjectcognition
dc.subjectcognition assessment
dc.subjectcognitive defect
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmetacognition
dc.subjectMetacognition Assessment Scale Abbreviated
dc.subjectneurocognition
dc.subjectoxytocin blood level
dc.subjectpriority journal
dc.subjectReading the Mind from the Eyes Test
dc.subjectschizophrenia
dc.subjectsocial cognition
dc.subjectvasopressin blood level
dc.subjectWisconsin Card Sorting Test
dc.subjectblood
dc.subjectcase control study
dc.subjectcognition
dc.subjectneuropsychological test
dc.subjectpathophysiology
dc.subjectperception
dc.subjectpsychology
dc.subjectschizophrenia
dc.subjectsocial behavior
dc.subjectyoung adult
dc.titleAssociations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia
dc.typeArticle

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