Evaluation of borate bioactive glass scaffolds with different pore sizes in a rat subcutaneous implantation model

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dc.contributor.authorDeliormanli A.M.
dc.contributor.authorLiu X.
dc.contributor.authorRahaman M.N.
dc.date.accessioned2024-07-22T08:17:50Z
dc.date.available2024-07-22T08:17:50Z
dc.date.issued2014
dc.description.abstractBorate bioactive glass has been shown to convert faster and more completely to hydroxyapatite and enhance new bone formation in vivo when compared to silicate bioactive glass (such as 45S5 and 13-93 bioactive glass). In this work, the effects of the borate glass microstructure on its conversion to hydroxyapatite (HA) in vitro and its ability to support tissue ingrowth in a rat subcutaneous implantation model were investigated. Bioactive borate glass scaffolds, designated 13-93B3, with a grid-like microstructure and pore widths of 300, 600, and 900 μm were prepared by a robocasting technique. The scaffolds were implanted subcutaneously for 4 weeks in Sprague Dawley rats. Silicate 13-93 glass scaffolds with the same microstructure were used as the control. The conversion of the scaffolds to HA was studied as a function of immersion time in a simulated body fluid. Histology and scanning electron microscopy were used to evaluate conversion of the bioactive glass implants to hydroxyapatite, as well as tissue ingrowth and blood vessel formation in the implants. The pore size of the scaffolds was found to have little effect on tissue infiltration and angiogenesis after the 4-week implantation. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
dc.identifier.DOI-ID10.1177/0885328212470013
dc.identifier.issn15308022
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17136
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBorates
dc.subjectGlass
dc.subjectProstheses and Implants
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectTissue Scaffolds
dc.subjectBioactive glass
dc.subjectBlood vessels
dc.subjectHydroxyapatite
dc.subjectMicrostructure
dc.subjectPore size
dc.subjectRats
dc.subjectScaffolds
dc.subjectScanning electron microscopy
dc.subjectSilicates
dc.subjectTissue
dc.subjectBioactive glass
dc.subjectpore size
dc.subjectrobocasting
dc.subjectscaffold
dc.subjectsubcutaneous implantation
dc.subjectboric acid
dc.subjectglass
dc.subjecthydroxyapatite
dc.subjectsilicate
dc.subjecttissue scaffold
dc.subjectDifferent pore sizes
dc.subjectGlass scaffolds
dc.subjectImplantation models
dc.subjectRobocasting
dc.subjectSimulated body fluids
dc.subjectSprague-Dawley rats
dc.subjectTissue in-growth
dc.subjectVessel formation
dc.subjectangiogenesis
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectbody fluid
dc.subjectchemical structure
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthistology
dc.subjectimmersion
dc.subjectimplantation
dc.subjectin vitro study
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectscanning electron microscopy
dc.subjectsimulation
dc.subjecttissue growth
dc.subjectScaffolds (biology)
dc.titleEvaluation of borate bioactive glass scaffolds with different pore sizes in a rat subcutaneous implantation model
dc.typeArticle

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