Glutamate mGlu5 receptor antagonist, MPEP, reduces the quinpirole-induced compulsive-like checking in rats

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dc.contributor.authorGök Ş.
dc.contributor.authorMurat Demet M.
dc.contributor.authorÖztürk Z.
dc.date.accessioned2024-07-22T08:10:22Z
dc.date.available2024-07-22T08:10:22Z
dc.date.issued2017
dc.description.abstractThere is increasing evidence for an interaction between dopaminergic and glutamatergic systems in obsessive-compulsive disorder (OCD). In the present study, it was tested whether group I metabotropic glutamate 5 receptors (mGlu5R) mediate compulsive-like checking behavior in an animal OCD model induced by quinpirole, a dopamine D2/3 receptor agonist. Rats were tested on a large open field with four boxes placed in different locations. To induce locomotor sensitization, rats were administered quinpirole chronically (0,5 mg kg-1, twice a week for 5 weeks, sc). In the treated group, 2-methyl-6-(phenyl ethynyl) pyridine (MPEP), an mGluR5 antagonist was administered to rats (1 or 5 mg kg−1, i.p.) prior to each quinpirole injection. The distance traveled and the speed of rats were used to assess locomotor activity. After each rat's checking place was identified, the number of visits and the length of check were used as the main criteria to assess the compulsive checking behavior. The results showed that treatment of MPEP significantly inhibited the increase in QNP-induced increase in locomotion and compulsive control behavior. Our findings, therefore, support the hypothesis that mGluR5 receptors mediate dopaminergic compulsive-like control behavior. © 2017
dc.identifier.DOI-ID10.1016/j.jocrd.2017.08.003
dc.identifier.issn22113649
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15204
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subject2 methyl 6 (phenyl ethynyl)pyridine
dc.subjectmetabotropic receptor 5
dc.subjectmetabotropic receptor antagonist
dc.subjectquinpirole
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectcompulsion
dc.subjectcompulsive like checking
dc.subjectcompulsive like checking
dc.subjectcontrolled study
dc.subjectdistance
dc.subjectdopaminergic system
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectlocomotion
dc.subjectmale
dc.subjectneurotransmission
dc.subjectnonhuman
dc.subjectphysical parameters
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectrat
dc.subjectregulatory mechanism
dc.subjectvelocity
dc.titleGlutamate mGlu5 receptor antagonist, MPEP, reduces the quinpirole-induced compulsive-like checking in rats
dc.typeArticle

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