Circulating manganese superoxide dismutase (Mn-SOD, SOD 2) levels and its Ala16Val polymorphism in patients with Alzheimer's disease; [Alzheimer hastaliǧi'nda serum mangan superoksd dismutaz (MnSOD, SOD 2) enzim düzeyleri ve Ala16Val gen polimorfizmi]

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dc.contributor.authorKilinç E.
dc.contributor.authorVar A.
dc.contributor.authorMavioǧlu H.
dc.contributor.authorDinç G.
dc.contributor.authorKaraçam M.
dc.contributor.authorGüvenç Y.
dc.date.accessioned2024-07-22T08:19:30Z
dc.date.available2024-07-22T08:19:30Z
dc.date.issued2012
dc.description.abstractIntroduction: Amyloid beta protein, DNA damage, oxygen free radicals and mitochondrial dysfunction are propounded mechanisms for pathogenesis of Alzheimer's disease (AD). In this study, we have focused on manganese superoxide dismutase (MnSOD, SOD-2), the most important scavenger enzyme in mitochondria. Ala16Val polymorphism, the most common variation in the SOD-2 gene, is considered to participate in the pathogenesis of neurodegenerative diseases. Therefore, in this study, we aimed to explain whether the MnSOD levels and its Ala16Val polymorphism are associated with Alzheimer's disease. Materials and Method: We determined the protein SOD-2 levels and its Ala16Val polymorphism in patients with AD (n=55) and control samples (n=62) from age and sex matched healthy volunteers. Real time pcr and spectrophotometry were used for the analyses of Ala16Val polymorphism and SOD-2 levels respectively. Results: We found significantly increased MnSOD levels in patients with Alzheimer's when compared to the healthy volunteers (144±67 U/gHb, 76±51 U/gHb respectively, p=0.001). But, there is no difference in Ala16Val polymorphism between the two groups. Conclusion: We consider that MnSOD is a critical antioxidant enzyme for mitochondrial vitality in Alzheimer patients, but its polymorphic structure does not contribute to pathophysiology of Alzheimer's.
dc.identifier.issn13079948
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17703
dc.language.isoEnglish
dc.subjectalanine
dc.subjectmanganese superoxide dismutase
dc.subjectscavenger
dc.subjectsuperoxide dismutase
dc.subjectvaline
dc.subjectAlzheimer disease
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectenzyme blood level
dc.subjectenzyme structure
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmitochondrion
dc.subjectpathogenesis
dc.subjectprotein polymorphism
dc.subjectreal time polymerase chain reaction
dc.subjectspectrophotometry
dc.titleCirculating manganese superoxide dismutase (Mn-SOD, SOD 2) levels and its Ala16Val polymorphism in patients with Alzheimer's disease; [Alzheimer hastaliǧi'nda serum mangan superoksd dismutaz (MnSOD, SOD 2) enzim düzeyleri ve Ala16Val gen polimorfizmi]
dc.typeArticle

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