Thiol/disulfide homeostasis in medication-naive children and adolescents with obsessive–compulsive disorder

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dc.contributor.authorOzkan Y.
dc.contributor.authorKandemir H.
dc.contributor.authorYalın Sapmaz S.
dc.contributor.authorTaneli F.
dc.contributor.authorOzdemir H.
dc.contributor.authorGozaçanlar Ozkan O.
dc.date.accessioned2024-07-22T08:05:46Z
dc.date.available2024-07-22T08:05:46Z
dc.date.issued2021
dc.description.abstractObsessive–compulsive disorder (OCD) causes significant psychic distress and affects children's social and academic functioning. Approximately 80% of OCD cases begin in childhood. Earlier onset is associated with more severe OC symptoms, poorer treatment response, and a more unfavorable clinical course. A particular oxidative stress marker, thiol/disulfide homeostasis, using a new, comparatively inexpensive, easily calculated, easily accessible, repeatable, and fully automated method was investigated between pediatric patients diagnosed with OCD and a healthy control group in this study. This study is the first to address this subject in pediatric patients with OCD and aims to contribute to our knowledge of the etiopathogenesis and treatment of pediatric OCD. The study included children with OCD (n = 35, 52.2%) (drug free, comorbidity free) between 11 and 18 years of age and age- and sex-matched healthy controls (n = 32, 47.8%). The total thiol (p = 0.025) and disulfide (p = 0.001) levels and the disulfide/native thiol (p = 0.001) and disulfide/total thiol ratios (p = 0.001) were significantly different between the groups. Also, in the patient group, biochemical analysis revealed that the disulfide level (p = 0.05) and the disulfide/native thiol (p = 0.034) and disulfide/total thiol ratios (p = 0.039) differed significantly according to the presence of a family history of psychiatric disorders. Consequently, the results of our study show that thiol/disulfide homeostasis may affect the etiopathogenesis of pediatric OCD and can be utilized as a new method when evaluating oxidative stress. © 2021 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.jpsychires.2021.05.084
dc.identifier.issn00223956
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13254
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectAdolescent
dc.subjectChild
dc.subjectComorbidity
dc.subjectDisulfides
dc.subjectHomeostasis
dc.subjectHumans
dc.subjectObsessive-Compulsive Disorder
dc.subjectSulfhydryl Compounds
dc.subjectdisulfide
dc.subjectthiol
dc.subjectdisulfide
dc.subjectthiol derivative
dc.subjectadolescent
dc.subjectadult
dc.subjectArticle
dc.subjectbiochemical analysis
dc.subjectcase control study
dc.subjectchild
dc.subjectclinical feature
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdisease duration
dc.subjectfamily history
dc.subjectfemale
dc.subjecthomeostasis
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectobsessive compulsive disorder
dc.subjectoxidative stress
dc.subjectpathogenesis
dc.subjectpediatric patient
dc.subjecttreatment response
dc.subjecthomeostasis
dc.subjectobsessive compulsive disorder
dc.titleThiol/disulfide homeostasis in medication-naive children and adolescents with obsessive–compulsive disorder
dc.typeArticle

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