Hepatic perfusion changes in an experimental model of acute pancreatitis: Evaluation by perfusion CT

Simple item page
dc.contributor.authorTutcu S.
dc.contributor.authorSerter S.
dc.contributor.authorKaya Y.
dc.contributor.authorKara E.
dc.contributor.authorNeşe N.
dc.contributor.authorPekindi G.
dc.contributor.authorCoşkun T.
dc.date.accessioned2024-07-22T08:21:11Z
dc.date.available2024-07-22T08:21:11Z
dc.date.issued2010
dc.description.abstractPurpose: It is known that acute pancreatitis may cause secondary changes in several organs. Liver is one of these involved organs. In different experimental studies hepatic damages were shown histopathologically in acute pancreatitis but there are a few studies about perfusion disorders that accompany these histopathologic changes. Perfusion CT (pCT) provides the ability to detect regional and global alterations in organ blood flow. The purpose of the study was to describe hepatic perfusion changes in experimental acute pancreatitis model with pCT. Materials and methods: Forty Sprague-Dawley rats of both genders with average weights of 250 g were used. Rats were randomized into two groups. Twenty rats were in control group and 20 in acute pancreatitis group. pCT was performed. Perfusion maps were formed by processing the obtained images with perfusion CT software. Blood flow (BF) and blood volume (BV) values were obtained from these maps. All pancreatic and liver tissues were taken off with laparotomy and histopathologic investigation was performed. Student's t test was used for statistical analyses. Results: In pCT we found statistically significant increase in blood volume in both lobes of liver and in blood flow in right lobe of the liver (p < 0.01). Although blood flow in left lobe of the liver increased, it did not reach statistical significance. Conclusion: The quantitative analysis of liver parenchyma with pCT showed that acute pancreatitis causes a significant perfusion changes in the hepatic tissue. Systemic mediators seem to be effective as well as local inflammatory changes in perfusion changes. © 2009 Elsevier Ireland Ltd.
dc.identifier.DOI-ID10.1016/j.ejrad.2009.04.072
dc.identifier.issn0720048X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18488
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectBlood
dc.subjectHemodynamics
dc.subjectRats
dc.subjectTissue
dc.subjectceruletide
dc.subjectiohexol
dc.subjectsodium chloride
dc.subjectAcute pancreatitis
dc.subjectExperimental modeling
dc.subjectHepatic tissue
dc.subjectLiver perfusion
dc.subjectPerfusion-ct
dc.subjectSprague-Dawley rats
dc.subjectStatistical significance
dc.subjectStudent's t tests
dc.subjectacute pancreatitis
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectblood volume
dc.subjectcomputed tomography scanner
dc.subjectcomputer assisted tomography
dc.subjectcontrolled study
dc.subjectexperimental model
dc.subjectfemale
dc.subjecthistopathology
dc.subjectlaparotomy
dc.subjectliver blood flow
dc.subjectliver perfusion
dc.subjectmale
dc.subjectnonhuman
dc.subjectpancreas
dc.subjectpriority journal
dc.subjectquantitative analysis
dc.subjectrat
dc.subjectComputerized tomography
dc.titleHepatic perfusion changes in an experimental model of acute pancreatitis: Evaluation by perfusion CT
dc.typeArticle

Files

Collections

Scopus Koleksiyonu