Black colored intervertebral disc; ochronosis: A case report; [Siyah renkli intervertebral disk; okronozis: Olgu sunumu]

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dc.contributor.authorÖsün A.
dc.contributor.authorKorkmaz M.
dc.contributor.authorTemiz P.
dc.contributor.authorSamancıoğlu A.
dc.contributor.authorAtay B.
dc.date.accessioned2024-07-22T08:11:20Z
dc.date.available2024-07-22T08:11:20Z
dc.date.issued2017
dc.description.abstractAlkaptonuria is a rare inborn error of metabolism caused by mutations in the gene responsible for the production of homogentisate 1,2-dioxygenase, an enzyme that plays an important role in the normal degradation of the aromatic amino acids tyrosine and phenylalanine. Defective production of this enzyme results in the accumulation of homogentisic acid, a tyrosine degradation product, in the bloodstream. Accumulation of homogentisic acid and its metabolites in tissues cause ochronosis. The word ochronosis refers to the dark bluish black discoloration of connective tissues including the sclera, cornea, auricular cartilage, heart valves, articular cartilage, tendons, and ligaments. In this article, we present a 38-year-old male patient with alkaptonuria associated degenerative L4-5 disc hernia, in which the patient was diagnosed after lumbar discectomy. © 2017 by Turkish Society of Physical Medicine and Rehabilitation.
dc.identifier.DOI-ID10.5606/tftrd.2017.03789
dc.identifier.issn13020234
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15609
dc.language.isoEnglish
dc.publisherTurkish Society of Physical Medicine and Rehabilitation
dc.rightsAll Open Access; Gold Open Access
dc.subjecthomogentisate 1,2 dioxygenase
dc.subjecthomogentisic acid
dc.subjectadult
dc.subjectalkaptonuria
dc.subjectArticle
dc.subjectcalcification
dc.subjectcase report
dc.subjectdiscectomy
dc.subjectfollow up
dc.subjectforaminotomy
dc.subjectgene mutation
dc.subjecthuman
dc.subjectinborn error of metabolism
dc.subjectintervertebral disk disease
dc.subjectleg pain
dc.subjectmale
dc.subjectneurologic examination
dc.subjectochronosis
dc.subjectradiography
dc.subjectrare disease
dc.subjecturine color
dc.titleBlack colored intervertebral disc; ochronosis: A case report; [Siyah renkli intervertebral disk; okronozis: Olgu sunumu]
dc.typeArticle

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