The protective role of thymoquinone in the prevention of gentamicin ototoxicity

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dc.contributor.authorSagit M.
dc.contributor.authorKorkmaz F.
dc.contributor.authorGürgen S.G.
dc.contributor.authorKaya M.
dc.contributor.authorAkcadag A.
dc.contributor.authorOzcan I.
dc.date.accessioned2024-07-22T08:15:39Z
dc.date.available2024-07-22T08:15:39Z
dc.date.issued2014
dc.description.abstractObjective To investigate the potential protective effect of thymoquinone in gentamicin-induced ototoxicity through auditory brain stem responses (ABR) testing and histomorphological evaluation of the cochlea.; Methods This study was conducted on 48 adult female Sprague-Dawley rats that were randomized into 4 groups. Group 1 received intraperitoneal gentamicin; group 2 received intraperitoneal gentamicin plus corn oil solution; group 3 received intraperitoneal thymoquinone; and group 4 received intraperitoneal gentamicin plus thymoquinone. All groups received the drugs (once daily) in the above-mentioned protocols over 15 days. After conducting repeated ABR measurements, the rats were sacrificed, and their cochleae were isolated.; Results ABR thresholds were preserved in the gentamicin plus thymoquinone group when compared with the group receiving gentamicin alone. There were fewer TUNEL-positive cells and caspase-3 and caspase-9 expressions were weaker in the inner and outer hairy cells of the organ of Corti in the gentamicin plus thymoquinone group compared with the group receiving gentamicin alone.; Conclusion The ABR values and number of apoptotic cells did not significantly increase in the group receiving gentamicin plus thymoquinone when compared to the group receiving gentamicin alone. Again, the cochlear histomorphological findings were supportive of the auditory findings. In light of these findings, we conclude that gentamicin-induced ototoxicity may be prevented by thymoquinone use in rats. © 2014 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.amjoto.2014.07.002
dc.identifier.issn01960709
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16753
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.subjectAnimals
dc.subjectBenzoquinones
dc.subjectCochlea
dc.subjectFemale
dc.subjectGentamicins
dc.subjectHearing Loss
dc.subjectIn Situ Nick-End Labeling
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectcaspase 3
dc.subjectcaspase 9
dc.subjectgentamicin
dc.subjectthymoquinone
dc.subjectbenzoquinone derivative
dc.subjectgentamicin
dc.subjectthymoquinone
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectbrain stem response
dc.subjectCorti organ
dc.subjectdrug effect
dc.subjectfemale
dc.subjectnonhuman
dc.subjectototoxicity
dc.subjectprotein expression
dc.subjecttreatment duration
dc.subjectanimal
dc.subjectchemically induced
dc.subjectcochlea
dc.subjectdrug effects
dc.subjectHearing Loss
dc.subjectrandomization
dc.subjectrat
dc.subjectSprague Dawley rat
dc.subjectTUNEL assay
dc.titleThe protective role of thymoquinone in the prevention of gentamicin ototoxicity
dc.typeArticle

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