Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts

Simple item page
dc.contributor.authorGok S.
dc.contributor.authorVural K.
dc.contributor.authorSekuri C.
dc.contributor.authorOnur R.
dc.contributor.authorTezcan A.
dc.contributor.authorIzanli A.
dc.date.accessioned2024-07-22T08:23:24Z
dc.date.available2024-07-22T08:23:24Z
dc.date.issued2006
dc.description.abstractActivation of ATP-sensitive K+ channels (KATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal KATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial KATP channel blocker on cardiac function and arrhythmias in isolated rat hearts. The hearts were subjected to 30 min coronary occlusion, followed by 30 min reperfusion. In the preischemic period, both HMR 1098 and 5-HD slightly increased coronary perfusion pressure. Coronary occlusion increased the perfusion pressure and decreased the left ventricular developed pressure (LVDP) in both control and drug-treated hearts. However, inhibition of LVDP was greater and recovery of the perfusion pressure was lower in 30 μmol/l HMR1098 and 100 μmol/l 5-HD-treated hearts compared to control (P < 0.05). HMR1098, at 3 μmol/l, but not at 30 μmol/l, significantly reduced the ratio of bigeminis, couplets and salvos (P < 0.05). Ventricular tachycardia and ventricular fibrillation were not prevented by HMR1098, at both concentrations, and with 5-HD (100 μmol/l). These results suggest that blockade of sarcKATP and mitoKATP channels exert weak antiarrhythmic action, but reduce the recovery of coronary perfusion and contractile force, implying that both types of KATP channels have beneficial role in the recovery of ischemic rat myocardium. © 2005 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.vph.2005.11.006
dc.identifier.issn15371891
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19525
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectArrhythmia
dc.subjectBenzamides
dc.subjectCoronary Circulation
dc.subjectDecanoic Acids
dc.subjectDose-Response Relationship, Drug
dc.subjectElectrocardiography
dc.subjectHeart
dc.subjectHeart Rate
dc.subjectHydroxy Acids
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectMyocardial Reperfusion Injury
dc.subjectMyocardium
dc.subjectPerfusion
dc.subjectPotassium Channel Blockers
dc.subjectPotassium Channels
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSarcolemma
dc.subjectVascular Resistance
dc.subjectVentricular Function, Left
dc.subject5 hydroxydecanoic acid
dc.subjectadenosine triphosphatase inhibitor
dc.subjectadenosine triphosphate sensitive potassium channel
dc.subjectclamikalant
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectcoronary artery blood flow
dc.subjectdrug effect
dc.subjectelectrocardiography
dc.subjectheart arrhythmia
dc.subjectheart contraction
dc.subjectheart function
dc.subjectheart hemodynamics
dc.subjectheart infarction
dc.subjectheart left ventricle pressure
dc.subjectheart muscle fiber membrane
dc.subjectheart muscle ischemia
dc.subjectheart muscle reperfusion
dc.subjectheart perfusion
dc.subjectheart rate
dc.subjectheart ventricle fibrillation
dc.subjectheart ventricle tachycardia
dc.subjecthemodynamic parameters
dc.subjectisolated heart
dc.subjectmale
dc.subjectnonhuman
dc.subjectperfusion pressure
dc.subjectpriority journal
dc.subjectrat
dc.titleEffects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts
dc.typeArticle

Files

Collections

Scopus Koleksiyonu