Interactions between Salivary Proteins and Apple Polyphenols and the Fate of Complexes during Gastric Digestion

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dc.contributor.authorBerkel Kasikci M.
dc.contributor.authorGuilois-Dubois S.
dc.contributor.authorBillet K.
dc.contributor.authorJardin J.
dc.contributor.authorGuyot S.
dc.contributor.authorMorzel M.
dc.date.accessioned2024-07-22T08:01:49Z
dc.date.available2024-07-22T08:01:49Z
dc.date.issued2024
dc.description.abstractBeneficial polyphenols in apples can reach the stomach as complexes formed with salivary proteins. The present study aimed at documenting the interactions between salivary proteins and cider apple polyphenols and the fate of complexes during gastric digestion. A polyphenolic extract was mixed with human saliva, and interactions were characterized by analyzing proteins and polyphenols in the insoluble and soluble fractions of the mixtures, before and after in vitro gastric digestion. Results confirmed that proline-rich proteins can efficiently precipitate polyphenols and suggested that two zinc-binding proteins can also form insoluble complexes with polyphenols. The classes of polyphenols involved in such complexes depended on the polyphenol-to-protein ratio. In vitro gastric digestion led to extensive proteolysis of salivary proteins, and we formulate the hypothesis that the resulting peptides can interact with and precipitate some procyanidins. Saliva may therefore partly modulate the bioaccessibility of at least procyanidins in the gastric compartment. © 2024 American Chemical Society
dc.identifier.DOI-ID10.1021/acs.jafc.4c00468
dc.identifier.issn00218561
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11580
dc.language.isoEnglish
dc.publisherAmerican Chemical Society
dc.subjectFlavonoids
dc.subjectFruits
dc.subjectApple polyphenol
dc.subjectCider apple
dc.subjectGastric digestions
dc.subjectHuman saliva
dc.subjectIn-vitro digestions
dc.subjectMalus domestica
dc.subjectPepsin
dc.subjectPolyphenols
dc.subjectProline-rich proteins
dc.subjectSalivary proteins
dc.subjectProteins
dc.titleInteractions between Salivary Proteins and Apple Polyphenols and the Fate of Complexes during Gastric Digestion
dc.typeArticle

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