Novel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) as potential radiotracers for heart imaging

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dc.contributor.authorLiu M.
dc.contributor.authorZheng Y.
dc.contributor.authorAvcibasi U.
dc.contributor.authorLiu S.
dc.date.accessioned2024-07-22T08:11:36Z
dc.date.available2024-07-22T08:11:36Z
dc.date.issued2016
dc.description.abstractIntroduction In this study, novel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (99mTc-ISboroxime-N3: R = IS; 99mTc-MPboroxime-N3: R = MP; 99mTc-PAboroxime-N3: R = PA; 99mTc-PYboroxime-N3: R = PY; and 99mTc-Uboroxime-N3: R = 5U) were evaluated as heart imaging agents. Methods Complexes [99mTc(N3)(CDO)(CDOH)2B-R] (R = IS, MP, PA, PY and 5U) were prepared by ligand exchange between NaN3 and [99mTcCl(CDO)(CDOH)2B-R]. Biodistribution and imaging studies were carried out in Sprague–Dawley rats. Image quantification was performed to compare their initial heart uptake and myocardial retention. Results 99mTc-ISboroxime-N3, 99mTc-PYboroxime-N3 and 99mTc-Uboroxime-N3 were prepared with high RCP (93–98%) while the RCP of 99mTc-MPboroxime-N3 and 99mTc-PAboroxime-N3 was 80–85%. The myocardial retention curves of 99mTc-ISboroxime-N3, 99mTc-PYboroxime-N3 and 99mTc-Uboroxime-N3 were best fitted to the bi-exponential decay function. The half-time of the fast component was 1.6 ± 0.4 min for 99mTc-ISboroxime-N3, 0.7 ± 0.1 min for 99mTc-PYboroxime-N3 and 0.9 ± 0.4 min for 99mTc-Uboroxime-N3. The 2-min heart uptake from biodistribution studies followed the ranking order of 99mTc-ISboroxime-N3 (3.60 ± 0.68%ID/g) > 99mTc-PYboroxime-N3 (2.35 ± 0.37%ID/g) ≫ 99mTc-Uboroxime-N3 (1.29 ± 0.06%ID/g). 99mTc-ISboroxime-N3 had the highest 2-min heart uptake among 99mTc radiotracers revaluated in SD rats. High quality SPECT images were obtained with the right and left ventricular walls being clearly delineated. The best image acquisition window was 0–5 min for 99mTc-ISboroxime-N3. Conclusion Both azide coligand and boronate caps had significant impact on the heart uptake and myocardial retention of complexes [99mTc(N3)(CDO)(CDOH)2B-R]. Among the radiotracers evaluated in SD rats, 99mTc-ISboroxime-N3 has the highest initial heart uptake with the heart retention comparable to that of 99mTc-Teboroxime. 99mTc-ISboroxime-N3 is a promising alternative to 99mTc-Teboroxime for SPECT MPI. © 2016 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.nucmedbio.2016.05.001
dc.identifier.issn09698051
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15715
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.rightsAll Open Access; Green Open Access
dc.subjectAnimals
dc.subjectHeart
dc.subjectImage Processing, Computer-Assisted
dc.subjectMyocardium
dc.subjectOrganotechnetium Compounds
dc.subjectOximes
dc.subjectRadioactive Tracers
dc.subjectRadiochemistry
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectTissue Distribution
dc.subjectTomography, Emission-Computed, Single-Photon
dc.subject99mTc 1h pyrazol 3 ylboronic acid boroxime
dc.subject99mTc 1h pyrazol 3 ylboronic acid boroxime n3
dc.subject99mTc 3 pyridineboronic acid boroxime
dc.subject99mTc 3 pyridineboronic acid boroxime n3
dc.subject99mTc isoxazole 4 boronic acid boroxime
dc.subject99mTc isoxazole 4 boronic acid boroxime n3
dc.subject99mTc n methylpyridinium 4 boronic acid iodide boroxime
dc.subject99mTc n methylpyridinium 4 boronic acid iodide boroxime n3
dc.subject99mTc teboroxime
dc.subject99mTc teboroxime n3
dc.subject99mTc trioxime
dc.subject99mTc trioxime n3
dc.subject99mTc uracil 5 boronic acid boroxime
dc.subject99mTc uracil 5 boronic acid boroxime n3
dc.subjecttracer
dc.subjectunclassified drug
dc.subjectoxime
dc.subjecttechnetium complex
dc.subjecttracer
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectcardiac imaging
dc.subjectcontrolled study
dc.subjectdynamic planar imaging
dc.subjectheart left ventricle wall
dc.subjectheart right ventricle
dc.subjectimage reconstruction
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance imaging
dc.subjectradiochemistry
dc.subjectrat
dc.subjectright ventricular wall
dc.subjectsingle photon emission computer tomography
dc.subjectSprague Dawley rat
dc.subjectanimal
dc.subjectcardiac muscle
dc.subjectchemistry
dc.subjectdiagnostic imaging
dc.subjectheart
dc.subjectimage processing
dc.subjectmetabolism
dc.subjectprocedures
dc.subjectsingle photon emission computed tomography
dc.subjecttissue distribution
dc.titleNovel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) as potential radiotracers for heart imaging
dc.typeArticle

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