Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo

Simple item page
dc.contributor.authorYasar A.
dc.contributor.authorGunduz K.
dc.contributor.authorOnur E.
dc.contributor.authorCalkan M.
dc.date.accessioned2024-07-22T08:19:44Z
dc.date.available2024-07-22T08:19:44Z
dc.date.issued2012
dc.description.abstractThe aim of this study was to determine serum vitamin B12, folic acid and homocysteine (Hcy) levels as well as MTHFR (C677, A1298C) gene polymorphisms in patients with vitiligo, and to compare the results with healthy controls. Forty patients with vitiligo and 40 age and sex matched healthy subjects were studied. Serum vitamin B12 and folate levels were determined by enzyme-linked immunosorbent assay. Plasma Hcy levels and MTHFR polymorphisms were determined by chemiluminescence and real time PCR methods, respectively. Mean serum vitamin B12 and Hcy levels were not significantly different while folic acid levels were significantly lower in the control group. There was no significant relationship between disease activity and vitamin B12, folic acid and homocystein levels. No significant difference in C677T gene polymorphism was detected. Heterozygote A1298C gene polymorphism in the patient group was statistically higher than the control group. There was no significant relationship between MTHFR gene polymorphisms and vitamin B12, folic acid and homocysteine levels. In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo. © 2012 - IOS Press and the authors. All rights reserved.
dc.identifier.DOI-ID10.3233/DMA-2012-0908
dc.identifier.issn02780240
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17820
dc.language.isoEnglish
dc.publisherHindawi Limited
dc.subjectcyanocobalamin
dc.subjectfolic acid
dc.subjecthomocysteine
dc.subjectmethylenetetrahydrofolate reductase (NADPH2)
dc.subjectadult
dc.subjectarticle
dc.subjectchemoluminescence
dc.subjectclinical article
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdisease activity
dc.subjectdisease predisposition
dc.subjectDNA polymorphism
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfolic acid blood level
dc.subjectgene mutation
dc.subjecthuman
dc.subjectmale
dc.subjectpriority journal
dc.subjectreverse transcription polymerase chain reaction
dc.subjectvitamin blood level
dc.subjectvitiligo
dc.titleSerum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo
dc.typeArticle

Files

Collections

Scopus Koleksiyonu