Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats

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dc.contributor.authorDemir B.C.
dc.contributor.authorUyar Y.
dc.contributor.authorOzbilgin K.
dc.contributor.authorKöse C.
dc.date.accessioned2024-07-22T08:19:03Z
dc.date.available2024-07-22T08:19:03Z
dc.date.issued2013
dc.description.abstractAim: The goal of this study was to investigate the combined effects of raloxifene and atorvastatin in aged ovariectomized rats during endothelial dysfunction and atherosclerotic process. Material and Methods: This study was conducted on 28Wistar albino female rats randomly divided into four groups. All groups were ovariectomized and one group was kept as the control group (OVX). For four weeks, the remaining three groups were treated with the statin atorvastatin (OVX+AV), the selective estrogen receptor modulator raloxifene (OVX+RL), and both atorvastatin and raloxifene (OVX+RL+AV), respectively. At the end of the treatment period, all rats were sacrificed and thoracic aortas excised, and endothelial cells were immunohistochemically stained for markers in the atherosclerotic process, such as inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), endothelin-1 (ET-1), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-α). Results: Compared to the ovariectomized group, the iNOS level was significantly increased in the OVX+RL group (P = 0.002), but contrarily decreased in the groups OVX+AV (P = 0.002) and OVX+RL+AV (P = 0.002). eNOS levels in the groups OVX+AV (P = 0.002) and OVX+RL+AV (P = 0.002) were significantly lower than that in the OVX group. When compared to the OVX group, significant reductions in ET-1 and TNF-α levels were found in all treatment groups. A significant decrement in MCP-1 level was found in the OVX+AV group (P = 0.002). Conclusion: In aged ovariectomized rats, the administration of both raloxifene and atorvastatin significantly decreased the levels of ET-1 and TNF-α on endothelial cells. Combined treatment with these drugs shortly after menopause might play a potential preventive role in the early stages of atherosclerosis development. © 2012 The Authors.
dc.identifier.DOI-ID10.1111/j.1447-0756.2012.01969.x
dc.identifier.issn14470756
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17480
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAorta, Thoracic
dc.subjectAtherosclerosis
dc.subjectChemokine CCL2
dc.subjectEndothelium, Vascular
dc.subjectEstrogen Antagonists
dc.subjectFemale
dc.subjectHeptanoic Acids
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.subjectNitric Oxide Synthase Type II
dc.subjectNitric Oxide Synthase Type III
dc.subjectOvariectomy
dc.subjectPyrroles
dc.subjectRaloxifene
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTumor Necrosis Factor-alpha
dc.subjectatorvastatin
dc.subjectendothelial nitric oxide synthase
dc.subjectendothelin 1
dc.subjectinducible nitric oxide synthase
dc.subjectmonocyte chemotactic protein 1
dc.subjectraloxifene
dc.subjecttumor necrosis factor alpha
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectendothelial dysfunction
dc.subjectendothelium
dc.subjectfemale
dc.subjectimmunohistochemistry
dc.subjectnonhuman
dc.subjectovariectomy
dc.subjectrat
dc.subjecttreatment duration
dc.titleEffect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats
dc.typeArticle

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