A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood

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dc.contributor.authorOzarda Y.
dc.contributor.authorIchihara K.
dc.contributor.authorBakan E.
dc.contributor.authorPolat H.
dc.contributor.authorOzturk N.
dc.contributor.authorBaygutalp N.K.
dc.contributor.authorTaneli F.
dc.contributor.authorGuvenc Y.
dc.contributor.authorOrmen M.
dc.contributor.authorErbayraktar Z.
dc.contributor.authorAksoy N.
dc.contributor.authorSezen H.
dc.contributor.authorDemir M.
dc.contributor.authorEskandari G.
dc.contributor.authorPolat G.
dc.contributor.authorMete N.
dc.contributor.authorYuksel H.
dc.contributor.authorVatansev H.
dc.contributor.authorGun F.
dc.contributor.authorAkin O.
dc.contributor.authorCeylan O.
dc.contributor.authorNoyan T.
dc.contributor.authorGozlukaya O.
dc.contributor.authorAliyazicioglu Y.
dc.contributor.authorKahraman S.
dc.contributor.authorDirican M.
dc.contributor.authorTuncer G.O.
dc.contributor.authorKimura S.
dc.contributor.authorEker P.
dc.date.accessioned2024-07-22T08:11:10Z
dc.date.available2024-07-22T08:11:10Z
dc.date.issued2017
dc.description.abstractIntroduction: A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). Materials and methods: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. RIs were computed by the parametric method with/without applying the LAVE method. Results: Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those RIs were derived for each manufacturer. RIs were determined from all volunteers’ results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific RIs were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific RIs were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. Conclusions: With the novel use of a freshly prepared blood panel, manufacturer-specific RIs’ were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in RIs were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude. © by Croatian Society of Medical Biochemistry and Laboratory Medicine.
dc.identifier.DOI-ID10.11613/BM.2017.038
dc.identifier.issn13300962
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15548
dc.language.isoEnglish
dc.publisherBiochemia Medica, Editorial Office
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectBlood Cell Count
dc.subjectFemale
dc.subjectHematologic Tests
dc.subjectHumans
dc.subjectLaboratories
dc.subjectLaboratory Proficiency Testing
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectQuality Control
dc.subjectReference Values
dc.subjectRegression Analysis
dc.subjectReproducibility of Results
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectferritin
dc.subjectadult
dc.subjectaged
dc.subjectanalytical parameters
dc.subjectArticle
dc.subjectblood clotting
dc.subjectblood sampling
dc.subjectfemale
dc.subjecthematological parameters
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectquality control
dc.subjectquestionnaire
dc.subjectred blood cell distribution width
dc.subjectreference value
dc.subjectadolescent
dc.subjectblood cell count
dc.subjectblood examination
dc.subjectclinical trial
dc.subjectdevices
dc.subjectgood laboratory practice
dc.subjectlaboratory
dc.subjectprocedures
dc.subjectreference value
dc.subjectregression analysis
dc.subjectreproducibility
dc.subjectstandards
dc.subjectTurkey
dc.subjectyoung adult
dc.titleA nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood
dc.typeArticle

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