Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients

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dc.contributor.authorEker C.
dc.contributor.authorKitis O.
dc.contributor.authorTaneli F.
dc.contributor.authorEker O.D.
dc.contributor.authorOzan E.
dc.contributor.authorYucel K.
dc.contributor.authorCoburn K.
dc.contributor.authorGonul A.S.
dc.date.accessioned2024-07-22T08:20:46Z
dc.date.available2024-07-22T08:20:46Z
dc.date.issued2010
dc.description.abstractThe hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between serum BDNF (sBDNF) levels and hippocampal volumes (HCV) of first-episode MDD patients (18 female, 7 male; mean age = 32.1 ± 9.3) and healthy controls (17 female, 5 male; mean age = 29.7 ± 6.4). Region of interest analysis was conducted on the images acquired via MRI. sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05). BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent as severe and multiple episodes are experienced. © 2010 Springer-Verlag.
dc.identifier.DOI-ID10.1007/s00406-010-0110-5
dc.identifier.issn09401334
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18311
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectBrain-Derived Neurotrophic Factor
dc.subjectDepression
dc.subjectFemale
dc.subjectFunctional Laterality
dc.subjectHippocampus
dc.subjectHumans
dc.subjectImmunoassay
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPsychiatric Status Rating Scales
dc.subjectStatistics as Topic
dc.subjectYoung Adult
dc.subjectbrain derived neurotrophic factor
dc.subjectadult
dc.subjectarticle
dc.subjectblood level
dc.subjectbrain size
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectfemale
dc.subjecthippocampus
dc.subjecthuman
dc.subjectmajor depression
dc.subjectmale
dc.subjectnervous system development
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectsymptom
dc.titleCorrelation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients
dc.typeArticle

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