Cutoff Values of MASK-air Patient-Reported Outcome Measures

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dc.contributor.authorSousa-Pinto B.
dc.contributor.authorSá-Sousa A.
dc.contributor.authorVieira R.J.
dc.contributor.authorAmaral R.
dc.contributor.authorPereira A.M.
dc.contributor.authorAnto J.M.
dc.contributor.authorKlimek L.
dc.contributor.authorCzarlewski W.
dc.contributor.authorMullol J.
dc.contributor.authorPfaar O.
dc.contributor.authorBedbrook A.
dc.contributor.authorBrussino L.
dc.contributor.authorKvedariene V.
dc.contributor.authorLarenas-Linnemann D.E.
dc.contributor.authorOkamoto Y.
dc.contributor.authorVentura M.T.
dc.contributor.authorAnsotegui I.J.
dc.contributor.authorBosnic-Anticevich S.
dc.contributor.authorCanonica G.W.
dc.contributor.authorCardona V.
dc.contributor.authorCecchi L.
dc.contributor.authorChivato T.
dc.contributor.authorCingi C.
dc.contributor.authorCosta E.M.
dc.contributor.authorCruz A.A.
dc.contributor.authorDel Giacco S.
dc.contributor.authorDevillier P.
dc.contributor.authorFokkens W.J.
dc.contributor.authorGemicioglu B.
dc.contributor.authorHaahtela T.
dc.contributor.authorIvancevich J.C.
dc.contributor.authorKuna P.
dc.contributor.authorKaidashev I.
dc.contributor.authorKraxner H.
dc.contributor.authorLaune D.
dc.contributor.authorLouis R.
dc.contributor.authorMakris M.
dc.contributor.authorMonti R.
dc.contributor.authorMorais-Almeida M.
dc.contributor.authorMösges R.
dc.contributor.authorNiedoszytko M.
dc.contributor.authorPapadopoulos N.G.
dc.contributor.authorPatella V.
dc.contributor.authorPham-Thi N.
dc.contributor.authorRegateiro F.S.
dc.contributor.authorReitsma S.
dc.contributor.authorRouadi P.W.
dc.contributor.authorSamolinski B.
dc.contributor.authorSheikh A.
dc.contributor.authorSova M.
dc.contributor.authorTaborda-Barata L.
dc.contributor.authorToppila-Salmi S.
dc.contributor.authorSastre J.
dc.contributor.authorTsiligianni I.
dc.contributor.authorValiulis A.
dc.contributor.authorYorgancioglu A.
dc.contributor.authorZidarn M.
dc.contributor.authorZuberbier T.
dc.contributor.authorFonseca J.A.
dc.contributor.authorBousquet J.
dc.date.accessioned2024-07-22T08:02:47Z
dc.date.available2024-07-22T08:02:47Z
dc.date.issued2023
dc.description.abstractBackground: In clinical and epidemiological studies, cutoffs of patient-reported outcome measures can be used to classify patients into groups of statistical and clinical relevance. However, visual analog scale (VAS) cutoffs in MASK-air have not been tested. Objective: To calculate cutoffs for VAS global, nasal, ocular, and asthma symptoms. Methods: In a cross-sectional study design of all MASK-air participants, we compared (1) approaches based on the percentiles (tertiles or quartiles) of VAS distributions and (2) data-driven approaches based on clusters of data from 2 comparators (VAS work and VAS sleep). We then performed sensitivity analyses for individual countries and for VAS levels corresponding to full allergy control. Finally, we tested the different approaches using MASK-air real-world cross-sectional and longitudinal data to assess the most relevant cutoffs. Results: We assessed 395,223 days from 23,201 MASK-air users with self-reported allergic rhinitis. The percentile-oriented approach resulted in lower cutoff values than the data-driven approach. We obtained consistent results in the data-driven approach. Following the latter, the proposed cutoff differentiating “controlled” and “partly-controlled” patients was similar to the cutoff value that had been arbitrarily used (20/100). However, a lower cutoff was obtained to differentiate between “partly-controlled” and “uncontrolled” patients (35 vs the arbitrarily-used value of 50/100). Conclusions: Using a data-driven approach, we were able to define cutoff values for MASK-air VASs on allergy and asthma symptoms. This may allow for a better classification of patients with rhinitis and asthma according to different levels of control, supporting improved disease management. © 2022 American Academy of Allergy, Asthma & Immunology
dc.identifier.DOI-ID10.1016/j.jaip.2022.12.005
dc.identifier.issn22132198
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11974
dc.language.isoEnglish
dc.publisherAmerican Academy of Allergy, Asthma and Immunology
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAsthma
dc.subjectCross-Sectional Studies
dc.subjectHumans
dc.subjectPatient Reported Outcome Measures
dc.subjectRhinitis
dc.subjectRhinitis, Allergic
dc.subjectbeta adrenergic receptor stimulating agent
dc.subjectcorticosteroid
dc.subjectmuscarinic receptor blocking agent
dc.subjectadult
dc.subjectallergic rhinitis
dc.subjectArticle
dc.subjectasthma
dc.subjectconjunctivitis
dc.subjectcross-sectional study
dc.subjectdisease duration
dc.subjectfemale
dc.subjecthuman
dc.subjectlongitudinal study
dc.subjectmachine learning
dc.subjectmale
dc.subjectpatient-reported outcome
dc.subjectquestionnaire
dc.subjectreliability
dc.subjectsensitivity analysis
dc.subjectsleep
dc.subjectvalidity
dc.subjectvisual analog scale
dc.subjectallergic rhinitis
dc.subjectasthma
dc.subjectpatient-reported outcome
dc.subjectrhinitis
dc.titleCutoff Values of MASK-air Patient-Reported Outcome Measures
dc.typeArticle

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