Airway epithelial barrier dysfunction in the pathogenesis and prognosis of respiratory tract diseases in childhood and adulthood

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dc.contributor.authorYuksel H.
dc.contributor.authorTurkeli A.
dc.date.accessioned2024-07-22T08:10:30Z
dc.date.available2024-07-22T08:10:30Z
dc.date.issued2017
dc.description.abstractThe lungs are in direct contact with the environment through the tubular structure that constitutes the airway. Starting from the nasal orifice, the airway is exposed to foreign particles including infectious agents, allergens, and other substances that can damage the airways. Therefore, the airway must have a functional epithelial barrier both in the upper and lower airways to protect against these threats. As with the skin, it is likely that the pathogenesis of respiratory diseases is a consequence of epithelial barrier defects in these airways. The characteristics of this system, starting from the beginning of life and extending into maturing and aging, determine the prognosis of respiratory diseases. In this article, we discuss the pathogenesis, clinical phenotype, and prognosis of respiratory diseases from newborns to adulthood in the context of epithelial barrier function and dysfunction. © 2017 Taylor & Francis.
dc.identifier.DOI-ID10.1080/21688370.2017.1367458
dc.identifier.issn21688362
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15269
dc.language.isoEnglish
dc.publisherTaylor and Francis Inc.
dc.rightsAll Open Access; Bronze Open Access; Green Open Access
dc.subjectAdult
dc.subjectAnimals
dc.subjectChild
dc.subjectHumans
dc.subjectPrognosis
dc.subjectRespiratory Mucosa
dc.subjectRespiratory Tract Diseases
dc.subjectTight Junctions
dc.subjectbeta adrenergic receptor stimulating agent
dc.subjectcatenin
dc.subjectcorticosteroid
dc.subjectdexamethasone
dc.subjectfluticasone propionate
dc.subjectmuscarinic receptor blocking agent
dc.subjecttight junction protein
dc.subjectuvomorulin
dc.subjectadherens junction
dc.subjectadulthood
dc.subjectairway epithelium cell
dc.subjectallergic rhinitis
dc.subjectasthma
dc.subjectcell maturation
dc.subjectcell polarity
dc.subjectchildhood
dc.subjectchronic obstructive lung disease
dc.subjectdesmosome
dc.subjectembryology
dc.subjectepidemiological monitoring
dc.subjectepithelial mesenchymal transition
dc.subjecthemidesmosome
dc.subjecthistology
dc.subjecthuman
dc.subjecthyperoxia
dc.subjectintracellular signaling
dc.subjectlower respiratory tract
dc.subjectlung dysplasia
dc.subjectmorbidity
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectpermeability barrier
dc.subjectphenotype
dc.subjectpolarization
dc.subjectprognosis
dc.subjectprotein expression
dc.subjectrespiratory epithelium
dc.subjectrespiratory tract disease
dc.subjectReview
dc.subjectstress
dc.subjecttight junction
dc.subjectupper respiratory tract
dc.subjectwheezing
dc.subjectadult
dc.subjectanimal
dc.subjectchild
dc.subjectmetabolism
dc.subjectpathophysiology
dc.subjectrespiratory mucosa
dc.subjectrespiratory tract disease
dc.titleAirway epithelial barrier dysfunction in the pathogenesis and prognosis of respiratory tract diseases in childhood and adulthood
dc.typeReview

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