The effect of lipoic acid on wound healing in a full thickness uterine injury model in rats

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dc.contributor.authorMicili S.C.
dc.contributor.authorGoker A.
dc.contributor.authorSayin O.
dc.contributor.authorAkokay P.
dc.contributor.authorErgur B.U.
dc.date.accessioned2024-07-22T08:18:30Z
dc.date.available2024-07-22T08:18:30Z
dc.date.issued2013
dc.description.abstractAim of this study was to investigate the effects of lipoic acid on uterine wound healing by immunohistochemical and biochemical assay in a rat uterine horn model with full thickness injury. Thirty-two female Wistar albino rats were randomised into five groups: Control group, with no intervention; uterine scar group 15days (US15d), uterine scar group 15 days + alpha lipoic acid (ALA) (US15d + ALA), uterine scar group 30 days (US30d) and uterine scar group 30 days + ALA (US30 days + ALA). After uterine incision 100 mg/kg of ALA was administered by oral gavage for either 15 or 30 days. Vascular endothelial growth factor (VEGF) and alpha smooth muscle actin (α-SMA) distribution were evaluated by immunohistochemical methods in tissue and ELISA methods in tissue homogenate. The percentage of α-SMA positive area in US15d + ALA and US30d + ALA groups was significantly higher than US15 and US30d groups. The percentage of VEGF positive area in US15d + ALA group was significantly higher than US15d group and US30d + ALA group was significantly higher than US30d group. Biochemically, α-SMA was significantly higher in the US15d + ALA group when compared to US15d group and higher in US30d + ALA group when compared to US30d group. VEGF was significantly higher in US15d + ALA and US30d + ALA groups when compared to US15 and US30d groups. In conclusion, ALA was found to be effective in enhancing wound healing in uterine full thickness injury. © 2013 Springer Science+Business Media Dordrecht.
dc.identifier.DOI-ID10.1007/s10735-013-9485-8
dc.identifier.issn15672387
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17330
dc.language.isoEnglish
dc.subjectActins
dc.subjectAnimals
dc.subjectCicatrix
dc.subjectFemale
dc.subjectMuscle, Smooth
dc.subjectNeovascularization, Physiologic
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRegeneration
dc.subjectThioctic Acid
dc.subjectUterus
dc.subjectVascular Endothelial Growth Factor A
dc.subjectWound Healing
dc.subjectRattus
dc.subjectalpha smooth muscle actin
dc.subjectthioctic acid
dc.subjectvasculotropin
dc.subjectangiogenesis
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfull thickness uterine injury
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectmouse
dc.subjectmuscle regeneration
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein localization
dc.subjectscar
dc.subjectsmooth muscle
dc.subjecttreatment duration
dc.subjecttreatment outcome
dc.subjectuterus disease
dc.subjectwound healing
dc.titleThe effect of lipoic acid on wound healing in a full thickness uterine injury model in rats
dc.typeArticle

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