The effects of melatonin and thymoquinone on doxorubicin- -induced cardiotoxicity in rats

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dc.contributor.authorYildiz Pehlivan D.
dc.contributor.authorDurdagi G.
dc.contributor.authorOz Oyar E.
dc.contributor.authorAkyol S.
dc.contributor.authorOzbek M.
dc.date.accessioned2024-07-22T08:08:02Z
dc.date.available2024-07-22T08:08:02Z
dc.date.issued2020
dc.description.abstractOBJECTIVES: This study aims to investigate the protective effects of thymoquinone and melatonin on the heart against doxorubicin-induced cardiotoxicity in rats. BACKGROUND: Melatonin and thymoquinone may play an important role in cardiotoxicity. METHODS: The subjects were divided into four groups: Control (physiological serum on 5th day), Doxorubicin (DXR), Doxorubicin+Melatonin (DXR+MEL, 10 mg/kg melatonin, intraperitoneally), and Doxorubicin+Thymoquinone (DXR+TQ, 50 mg/kg thymoquinone, orally). On the 5th day of the experiment, all groups were injected with 45 mg/kg DXR into the tail vein. On the 8th day of the experiment, ECG recordings were performed under anaesthesia. RESULTS: Thymoquinone reduced the PR, QRS and QTc intervals, which were increased by DXR, while melatonin only reduced the QTc interval. Melatonin had a protective effect against the histopathological changes induced by DXR, while TQ did not demonstrate such an effect. DXR increased CK-MB, IL-6, MDA, IL-1, IL-18 levels and decreased SOD in the cardiac tissue. MEL reduced the levels of CK-MB, MDA, NO, SOD, IL-1, IL-6, IL-18. Meanwhile, TQ only reduced CK-MB, IL-1 and IL-18. CONCLUSION: Our study showed that DXR induces cardiac injury and that melatonin improves biochemical parameters and offers histological protection; while thymoquinone improves ECG parameters and causes partial recovery of biochemical parameters (Tab. 4, Fig. 2, Ref. 41). Text in PDF www.elis.sk. © 2020.
dc.identifier.DOI-ID10.4149/BLL_2020_123
dc.identifier.issn00069248
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14229
dc.language.isoEnglish
dc.publisherComenius University in Bratislava
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectAntibiotics, Antineoplastic
dc.subjectBenzoquinones
dc.subjectCardiotoxicity
dc.subjectDoxorubicin
dc.subjectHeart
dc.subjectMelatonin
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectantineoplastic antibiotic
dc.subjectbenzoquinone derivative
dc.subjectdoxorubicin
dc.subjectmelatonin
dc.subjectthymoquinone
dc.subjectanimal
dc.subjectcardiotoxicity
dc.subjectheart
dc.subjectrat
dc.subjectWistar rat
dc.titleThe effects of melatonin and thymoquinone on doxorubicin- -induced cardiotoxicity in rats
dc.typeArticle

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