Small cell Carcinomas of the bladder highly express somatostatin receptor type 2A: Impact on prognosis and treatment-a multicenter study of urooncology society, Turkey

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dc.contributor.authorNese N.
dc.contributor.authorKumbaraci B.S.
dc.contributor.authorBaydar D.E.
dc.contributor.authorKilicaslan I.
dc.contributor.authorSari A.A.
dc.contributor.authorSen S.
dc.contributor.authorGonul I.I.
dc.contributor.authorKankaya D.
dc.contributor.authorOzluk Y.
dc.contributor.authorErmete M.
dc.contributor.authorOzagari A.
dc.contributor.authorBal N.
dc.contributor.authorKiremitci S.
dc.contributor.authorYildiz K.
dc.contributor.authorTuna B.
dc.contributor.authorSen N.
dc.contributor.authorYorukoglu K.
dc.date.accessioned2024-07-22T08:12:38Z
dc.date.available2024-07-22T08:12:38Z
dc.date.issued2016
dc.description.abstractSmall cell carcinoma (SmCC) is a rare and aggressive neuroendocrine carcinoma of the bladder. Neuroendocrine carcinomas expressing somatostatin receptors (SSTR) in other viscera such as lung, pancreas, and gastrointestinal system respond to therapy with somatostatin analogs. In the present study, expressions of SSTRs 1 to 5 including type 2A are investigated by immunohistochemistry (IHC) and their relationship with clinicopathologic factors was evaluated. Hundred primary bladder SmCC cases were collected from 12 centers in Turkey. Forty-three cases were pure SmCC. Other cases had mostly papillary urothelial carcinoma as a second component. The percentage of the SmCC component ranged from 5% to 100%. SSTR-2A expression was membranous, whereas the other receptors showed cytoplasmic staining. The percentages of positive cases for SSTR-1, SSTR-2A, SSTR-3, SSTR-4, and SSTR-5 were 4% (3/75), 61.4% (54/88), 2.4% (2/84), 24.4% (20/82), and 6.25% (5/80), respectively. The percentage of SmCC component was positively correlated with the percentage of SSTR-2A expression (P=0.003) while negatively correlated with patient age (P=0.032). SSTR-2A expression was correlated with survival as a bad prognostic factor (P=0.018). SSTR-1, SSTR-3, SSTR-4, and SSTR-5 expressions did not show any statistical significance with any parameter. In conclusion, although the limited number of cases with adequate term follow-up, SSTR-2A expression could be a prognostic factor and somatostatin analogs therapeutic candidate for SmCCs of the bladder as these tumors show high percentage of SSTR-2A expression. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
dc.identifier.DOI-ID10.1097/PAI.0000000000000188
dc.identifier.issn15412016
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16137
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomarkers, Tumor
dc.subjectCarcinoma, Small Cell
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectReceptors, Somatostatin
dc.subjectUrinary Bladder Neoplasms
dc.subjectsomatostatin derivative
dc.subjectsomatostatin receptor
dc.subjectsomatostatin receptor 1
dc.subjectsomatostatin receptor 2A
dc.subjectsomatostatin receptor 3
dc.subjectsomatostatin receptor 4
dc.subjectsomatostatin receptor 5
dc.subjectunclassified drug
dc.subjectsomatostatin receptor
dc.subjectsomatostatin receptor 2
dc.subjecttumor marker
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbladder cancer
dc.subjectbladder small cell carcinoma
dc.subjectcancer prognosis
dc.subjectcancer survival
dc.subjectcancer therapy
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmale
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectsmall cell carcinoma
dc.subjecttransitional cell carcinoma
dc.subjectTurkey (republic)
dc.subjectbladder tumor
dc.subjectclinical trial
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectprognosis
dc.subjectsmall cell carcinoma
dc.subjectvery elderly
dc.titleSmall cell Carcinomas of the bladder highly express somatostatin receptor type 2A: Impact on prognosis and treatment-a multicenter study of urooncology society, Turkey
dc.typeArticle

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