Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with 131I

Simple item page
dc.contributor.authorAvcibaşi U.
dc.contributor.authorAvcibaşi N.
dc.contributor.authorÜnak T.
dc.contributor.authorÜnak P.
dc.contributor.authorMüftüler F.Z.
dc.contributor.authorYildirim Y.
dc.contributor.authorDinçalp H.
dc.contributor.authorGümüşer F.G.
dc.contributor.authorDursun E.R.
dc.date.accessioned2024-07-22T08:22:20Z
dc.date.available2024-07-22T08:22:20Z
dc.date.issued2008
dc.description.abstractThe metabolic comparison of aniline- and phenol-phthaleins radiolabeled with 131I (131I-APH and 131I-PPH, respectively) has been investigated in this study. To compare the metabolic behavior of these phthaleins and their glucuronide conjugates radiolabeled with 131I, scintigraphic and biodistributional techniques were applied using male Albino rabbits. The results obtained have shown that these compounds were successfully radioiodinated with a radioiodination yield of about 100%. Maximum uptakes of 131I-APH and 131I-PPH, which were metabolized as N- and O-glucuronides, were observed within 2 h in the bladder and in the small intestine, respectively. In the case of verification of considerably up taking of these compounds also by tumors developed in the small intestine and in the bladder tissues, these results can be expected to be encouraging to test these compounds, which will be radiolabeled with other radioiodines such as 125I, 123I and 124I as imaging and therapeutic agents in nuclear medical applications. © 2008 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.nucmedbio.2008.02.003
dc.identifier.issn09698051
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19041
dc.language.isoEnglish
dc.subjectAniline Compounds
dc.subjectAnimals
dc.subjectChromatography, Liquid
dc.subjectGlucuronides
dc.subjectIntestinal Neoplasms
dc.subjectIntestine, Small
dc.subjectIodine Radioisotopes
dc.subjectMale
dc.subjectMass Spectrometry
dc.subjectPhenolphthalein
dc.subjectRabbits
dc.subjectRadionuclide Imaging
dc.subjectRadiopharmaceuticals
dc.subjectSpectrophotometry
dc.subjectTissue Distribution
dc.subjectUrinary Bladder
dc.subjectUrinary Bladder Neoplasms
dc.subjectaniline phthalein i 131
dc.subjectglucuronide
dc.subjectphenol phathalein i 131
dc.subjectradiopharmaceutical agent
dc.subjectanimal experiment
dc.subjectarticle
dc.subjectbladder
dc.subjectcontrolled study
dc.subjectdrug distribution
dc.subjectdrug metabolism
dc.subjectdrug uptake
dc.subjectisotope labeling
dc.subjectmale
dc.subjectnonhuman
dc.subjectrabbit
dc.subjectsmall intestine
dc.titleMetabolic comparison of radiolabeled aniline- and phenol-phthaleins with 131I
dc.typeArticle

Files

Collections

Scopus Koleksiyonu