Effects of interferon-α-2b and octreotide on healing of esophageal corrosive burns

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dc.contributor.authorKaygusuz I.
dc.contributor.authorçelįk O.
dc.contributor.authorÖzkaya Ö.
dc.contributor.authorYalçin S.
dc.contributor.authorKeleş E.
dc.contributor.authorçetįnkaya T.
dc.date.accessioned2024-07-22T08:25:23Z
dc.date.available2024-07-22T08:25:23Z
dc.date.issued2001
dc.description.abstractObjective The aim of this study was to investigate the effect of interferon-α to 2b and octreotide on the treatment of esophagus corrosive burns. Method The experimental study was performed on 63 rabbits. Burn was obtained by treating a segment, isolated in cervical esophagus, with NAOH. The rabbits were allocated into three groups (control, interferon, and octreotide). On the fourth, eighth, and 20th days, 7 rabbits randomly selected from each group were killed. Comparisons among the groups were made by taking histopathologic findings, stenosis index, and hydroxyproline production into consideration. Cross-tabulation and analysis of variance tests were used for statistical analysis. Results There were no statistically significant differences among the groups in terms of epithelial changes, extension of inflammation, and severity of fibrosis. In terms of severity of inflammation, there was a statistically significant difference between the control and the other two groups. Also, a significant difference was found between the control group and the other two groups in terms of extension of fibrosis on the 20th day. The difference between the control and the two treatment groups was significant on the eighth day and the 20th day measurements. Comparison of the hydroxyproline values showed a statistically significant difference between the octreotide group and the other two groups on the eighth and 20th days. Conclusion Histopathologic and biochemical findings indicate that, by hindering fibrosis progress, octreotide (and interferon) might be new and promising alternatives in the treatment of corrosive burns of the esophagus. © 2001 The American Laryngological, Rhinological and Otalogical Society, Inc.
dc.identifier.DOI-ID10.1097/00005537-200111000-00025
dc.identifier.issn0023852X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20379
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBurns, Chemical
dc.subjectEsophageal Stenosis
dc.subjectEsophagus
dc.subjectFibrosis
dc.subjectInterferon Alfa-2b
dc.subjectOctreotide
dc.subjectRabbits
dc.subjectTime Factors
dc.subjectWound Healing
dc.subjecthydroxyproline
dc.subjectoctreotide
dc.subjectrecombinant alpha2b interferon
dc.subjectsodium hydroxide
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectdrug effect
dc.subjectesophagitis
dc.subjectesophagus burn
dc.subjectesophagus stenosis
dc.subjectfibrosis
dc.subjecthealing
dc.subjecthistopathology
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectstatistical analysis
dc.titleEffects of interferon-α-2b and octreotide on healing of esophageal corrosive burns
dc.typeArticle

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