Comparison of the effects of contractubex ® gel in an experimental model of scar formation in rats: An immunohistochemical and ultrastructural study

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dc.contributor.authorSahin M.T.
dc.contributor.authorInan S.
dc.contributor.authorOzturkcan S.
dc.contributor.authorGuzel E.
dc.contributor.authorBilac C.
dc.contributor.authorGiray G.
dc.contributor.authorMuftuoglu S.
dc.date.accessioned2024-07-22T08:19:54Z
dc.date.available2024-07-22T08:19:54Z
dc.date.issued2012
dc.description.abstractBackground: Contractubex® gel, a commercial treatment for scars, consists of a mixture of onion extract (cepea extract), heparin sodium, and allantoin. It exerts a softening and smoothing effect on indurated, hypertrophic, painful, and cosmetically-disfiguring scar tissue. Aim: To compare and discuss the immunohistochemical and ultrastructural effects of treatment of an experimental scar in a rat model with Contractubex gel. Methods: Thirty-two Sprague-Dawley rats were divided into four groups. Skin biopsies were taken to develop full thickness wounds. After 10 days, Contractubex gel, heparin, and allantoin were topically applied daily to groups 2, 3, and 4, respectively. Group 1 was the control group. On the 30th day, scar tissues were excised to investigate the immunohistochemical and ultrastructural effects of these agents. For this purpose we used TGF-beta, laminin, and fibronectin primary antibodies. Results: Increased immunoreactivities of laminin, fibronectin, and TGF-beta in control group, moderate immunoreactivities in heparin and allantoin groups, and mild immunoreactivities in the Contractubex gel group were observed. In semi-thin sections, Group 2 showed the thinnest epidermis of the four groups. In electron micrographs of Group 2, completely keratinized and normally appearing cells could be seen. Conclusions: Immunohistochemical and ultrastructural observations demonstrated that the Contractubex gel significantly improved the quality of wound healing and reduction of scar formation. Also, it was a more appropriate treatment choice than heparin monotherapy and allantoin monotherapy in keloidal and hypertrophic scars. COPYRIGHT © 2012.
dc.identifier.issn15459616
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17889
dc.language.isoEnglish
dc.subjectAdministration, Topical
dc.subjectAllantoin
dc.subjectAnimals
dc.subjectCicatrix
dc.subjectDisease Models, Animal
dc.subjectDrug Combinations
dc.subjectFemale
dc.subjectGels
dc.subjectHeparin
dc.subjectPlant Extracts
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSkin
dc.subjectTreatment Outcome
dc.subjectallantoin
dc.subjectcontractubex
dc.subjectfibronectin
dc.subjectheparin
dc.subjectlaminin
dc.subjecttransforming growth factor beta
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectelectron microscopy
dc.subjectepidermis
dc.subjectfemale
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectkeratinocyte
dc.subjectnonhuman
dc.subjectrat
dc.subjectscar formation
dc.subjectskin biopsy
dc.subjectwound
dc.subjectwound healing
dc.titleComparison of the effects of contractubex ® gel in an experimental model of scar formation in rats: An immunohistochemical and ultrastructural study
dc.typeArticle

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