Determination of cocaine in urine by GC/MS method; [GC/MS yöntemi̇ i̇le i̇drarda kokai̇n tayi̇ni̇]

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dc.contributor.authorCengiz G.
dc.contributor.authorÇeçen Ş.Ş.
dc.contributor.authorSöylemezoǧlu T.
dc.date.accessioned2024-07-22T08:24:32Z
dc.date.available2024-07-22T08:24:32Z
dc.date.issued2004
dc.description.abstractAlthough there are not enough researches in our country about drug abuse depending upon toxicological analysis, there is an impression that cocaine abuse is becoming widespread from current data. As a result, appropriate analytical toxicological method should be established in order to determine the drug abuse. Cocaine is a natural alkaloid that is toxic to central nervous system, heart, liver, neuromuscular system and kidneys. Widespread abuse of cocaine is an important health problem in society. Cocaine is usually misused with ethanol, opioids, marihuana and sedative hypnotics. In our study, qualitative and quantitative methods are established to determine cocaine levels from urine by GC/MS (gas chromatography mass spectrometry). Precision, accuracy, specificity of the established method is evaluated. In order to isolate cocaine from urine, liquid-liquid and solid phase extraction methods are applied and compared. Recovery rates of 77.6% by liquid-liquid extraction method and 81.2% by SPE method were obtained. In one of the suspicious urine samples, morphine is determined besides methylecgonine and benzoylecgonine.
dc.identifier.issn10153918
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20016
dc.language.isoTurkish
dc.publisherUniversity of Ankara
dc.subjectbenzoylecgonine
dc.subjectcocaine
dc.subjectecgonine methyl ester
dc.subjectmorphine
dc.subjectaccuracy
dc.subjectarticle
dc.subjectcocaine dependence
dc.subjectdrug urine level
dc.subjectgas chromatography
dc.subjecthuman
dc.subjectintermethod comparison
dc.subjectliquid liquid extraction
dc.subjectmass spectrometry
dc.subjectqualitative analysis
dc.subjectquantitative analysis
dc.subjectsensitivity and specificity
dc.subjectsolid phase extraction
dc.subjecturinalysis
dc.titleDetermination of cocaine in urine by GC/MS method; [GC/MS yöntemi̇ i̇le i̇drarda kokai̇n tayi̇ni̇]
dc.typeArticle

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