Plasma selenium and urinary iodine in patients with goiter

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dc.contributor.authorHekimsoy Z.
dc.contributor.authorBiberoglu S.
dc.contributor.authorKirkali G.
dc.contributor.authorBicer N.
dc.contributor.authorErbayraktar Z.
dc.date.accessioned2024-07-22T08:24:33Z
dc.date.available2024-07-22T08:24:33Z
dc.date.issued2004
dc.description.abstractObjective: Iodine deficiency and related disorders are still major public health problems, with a high prevalence of endemic goiter in many regions of Turkey. In addition to measuring iodine excretion rates in patients with diffuse or nodular goiter, we examined plasma selenium concentrations, to see whether selenium deficiency might be related to goiterogenesis in our region. Methods: Seventy-two outpatients with goiter (67 female, 5 male; age 43.7 ± 13.0 years) presenting consecutively to our university medical center endocrinology clinic, were included in the study group. The control group consisted of 30 subjects (25 female, 5 male; age 40.6 ± 13.6 years) who were healthy and did not have any known thyroid disease. None of the subjects were using medications containing selenium or iodine. Serum thyroid hormones, plasma selenium and urinary iodine levels were measured, and an ultrasound of the thyroid was performed in both groups. Results: Serum thyroid hormone levels were in the normal range in both groups and the difference was not significant. Mean plasma selenium levels in the study and control groups were not significantly different (p = 0.30). However, urinary iodine excretion was significantly lower in the study group (17.4 ± 12.6 μg/l vs 23.2 ± 12.2 μg/l, p = 0.03). In both study and control group patients, a significant negative correlation between thyroid volume and urinary iodine levels was observed. Conclusion: Moderate to severe iodine deficiency is the primary etiologic factor for endemic goiter in our region. Plasma selenium levels were not related to the presence or absence of goiter in our population.
dc.identifier.DOI-ID10.5414/tep21145
dc.identifier.issn09462104
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20024
dc.language.isoEnglish
dc.publisherDustri-Verlag Dr. Karl Feistle
dc.subjectiodine
dc.subjectselenium
dc.subjectthyroid hormone
dc.subjectadult
dc.subjectarticle
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectfemale
dc.subjectgoiter
dc.subjecthuman
dc.subjectiodine deficiency
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoutpatient
dc.subjectpriority journal
dc.subjectselenium deficiency
dc.subjectthyroid disease
dc.subjectthyroid hormone blood level
dc.subjectTurkey (republic)
dc.subjecturine level
dc.titlePlasma selenium and urinary iodine in patients with goiter
dc.typeArticle

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