First trimester ultrasound screening for Down syndrome based on maternal age, fetal nuchal translucency and different combinations of the additional markers nasal bone, tricuspid and ductus venosus flow

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dc.contributor.authorAbele H.
dc.contributor.authorWagner P.
dc.contributor.authorSonek J.
dc.contributor.authorHoopmann M.
dc.contributor.authorBrucker S.
dc.contributor.authorArtunc-Ulkumen B.
dc.contributor.authorKagan K.O.
dc.date.accessioned2024-07-22T08:12:33Z
dc.date.available2024-07-22T08:12:33Z
dc.date.issued2015
dc.description.abstractObjective: To examine the performance of screening for Down syndrome based on maternal age, fetal nuchal translucency (NT) and different combinations of the additional ultrasound parameters: nasal bone (NB), tricuspid flow (TF) and ductus venosus (DV). Methods: Retrospective study at the University of Tuebingen, Germany including women who underwent chorionic villous sampling between 2008 and 2014. Prior to invasive testing, the crown rump length, NT, NB, TF and DV were measured. In each case, the added value of the additional markers NB, TF and DV were compared with screening for trisomy 21 based on maternal age (MA) and NT thickness alone. Results: A total of 1916 pregnancies met the inclusion criteria, including 1823 fetuses with a normal karyotype and 93 with trisomy 21. Screening based on MA, fetal NT and one, two and three of the additional ultrasound markers resulted in a detection rate of about 80%, 87% and 94%, respectively for a false positive rate of 3%. Conclusion: Detection rates for trisomy 21 in first trimester ultrasound screening are substantially higher if all three additional markers rather than just one are assessed. © 2015 John Wiley & Sons, Ltd.
dc.identifier.DOI-ID10.1002/pd.4664
dc.identifier.issn01973851
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16103
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Ltd
dc.subjectDown Syndrome
dc.subjectFemale
dc.subjectFetal Heart
dc.subjectHumans
dc.subjectMaternal Age
dc.subjectNasal Bone
dc.subjectNuchal Translucency Measurement
dc.subjectPregnancy
dc.subjectPregnancy Trimester, First
dc.subjectRetrospective Studies
dc.subjectTricuspid Valve Insufficiency
dc.subjectaneuploidy
dc.subjectArticle
dc.subjectcrown rump length
dc.subjectDown syndrome
dc.subjectductus venosus
dc.subjectfemale
dc.subjectfetal nuchal translucency
dc.subjectfirst trimester pregnancy
dc.subjectGermany
dc.subjecthuman
dc.subjectkaryotype
dc.subjectkaryotyping
dc.subjectmajor clinical study
dc.subjectmaternal age
dc.subjectnasal bone
dc.subjectnuchal translucency measurement
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectrisk assessment
dc.subjectscreening
dc.subjecttricuspid flow
dc.subjecttrisomy 21
dc.subjectdiagnostic imaging
dc.subjectDown syndrome
dc.subjectfetus heart
dc.subjectfirst trimester pregnancy
dc.subjectnasal bone
dc.subjectpregnancy
dc.subjecttricuspid valve regurgitation
dc.titleFirst trimester ultrasound screening for Down syndrome based on maternal age, fetal nuchal translucency and different combinations of the additional markers nasal bone, tricuspid and ductus venosus flow
dc.typeArticle

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