Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion
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Date
2005
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Abstract
Polyamines have been shown to play an important role in the disturbance of the blood-brain barrier (BBB) in a number of pathological states including ischemia. BBB disturbances may be almost completely prevented by treating animals with the ornithine decarboxylase (ODC) inhibitor, α- difluoromethylornithine (DFMO). DFMO has been also shown to prevent N-Methyl-d-aspartate (NMDA) toxicity in tissue cultures. It has been suggested that the pathological disturbances in polyamine metabolism observed following cerebral ischemia, particularly the post-ischemic increase in putrescine, may contribute to the ischemic injury that is most evident in the CA1 subfield of the hippocampus. In this study, effects of DFMO in cerebral ischemia and reperfusion were examined. The results showed that inhibition of the polyamine system by DFMO decreased ischemic injury volume and brain tissue water content in a dose-dependent manner, without change in vital signs, including systemic arterial blood pressure, arterial partial oxygen pressure, regional cerebral blood flow and body temperature. © 2005 Published by Elsevier Ltd.
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Animals , Brain Edema , Cerebral Infarction , Cerebrovascular Circulation , Disease Models, Animal , Dose-Response Relationship, Drug , Eflornithine , Enzyme Inhibitors , Infarction, Middle Cerebral Artery , Intracranial Pressure , Rats , Rats, Inbred SHR , Reperfusion Injury , eflornithine , animal model , animal tissue , arterial pressure , article , blood brain barrier , body temperature , brain blood flow , brain ischemia , brain size , controlled study , dose response , inhibition kinetics , middle cerebral artery occlusion , nonhuman , oxygen tension , priority journal , reperfusion injury