Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam

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dc.contributor.authorKeleş G.T.
dc.contributor.authorKurutepe S.
dc.contributor.authorTok D.
dc.contributor.authorGazi H.
dc.contributor.authorDinç G.
dc.date.accessioned2024-07-22T08:23:09Z
dc.date.available2024-07-22T08:23:09Z
dc.date.issued2006
dc.description.abstractBackground and objectives: The aim of our study was to investigate the antimicrobial effects of dexmedetomidine and etomidate-lipuro, and to compare these effects with those of midazolam and propofol on Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Acinetobacter baumannii and extended-spectrum beta-lactamase Escherichia coli ( E. coli ESBL). Methods: All hypnotic dilutions were exposed to micro-organisms for 0, 30, 60, 120 and 240 min at room temperature in vitro. The inoculums taken from diluted suspensions were re-inoculated on blood agar and incubated for 18-24 h at 35°C after which a count of the colonies was compared. Results: Midazolam reduced the viable cells of S. aureus at 30, 60, 120 and 240 min, and also completely inhibited the growth of E. coli, P. aeroginosa, A. baumannii and E. coli ESBL. Dexmedetomidine, etomidate-lipuro and propofol, however, did not inhibit any of the micro-organisms tested. Conclusion: In vitro, midazolam had an antimicrobial effect on E. coli, P. aeroginosa, A. baumannii and E. coli ESBL. Like propofol and dexmedetomidine, etomidate-lipuro had no antimicrobial effect on any of the micro-organisms tested. © 2006 Copyright European Society of Anaesthesiology.
dc.identifier.DOI-ID10.1017/S0265021506000949
dc.identifier.issn13652346
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19391
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAcinetobacter baumannii
dc.subjectAdrenergic alpha-Agonists
dc.subjectAnesthetics, Intravenous
dc.subjectAnti-Infective Agents
dc.subjectDexmedetomidine
dc.subjectDrug Evaluation, Preclinical
dc.subjectEquipment Contamination
dc.subjectEscherichia coli
dc.subjectEtomidate
dc.subjectHumans
dc.subjectMidazolam
dc.subjectPropofol
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.subjectTemperature
dc.subjectTime Factors
dc.subjectagar
dc.subjectantiinfective agent
dc.subjectdexmedetomidine
dc.subjectetomidate
dc.subjectmidazolam
dc.subjectpropofol
dc.subjectAcinetobacter baumannii
dc.subjectantimicrobial activity
dc.subjectarticle
dc.subjectbacterial count
dc.subjectbacterial growth
dc.subjectbacterium colony
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectEscherichia coli
dc.subjectin vitro study
dc.subjectinoculation
dc.subjectintensive care psychosis
dc.subjectnonhuman
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.titleComparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam
dc.typeArticle

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