Effects of boric acid on bone formation after maxillary sinus floor augmentation in rabbits

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dc.contributor.authorUlu M.
dc.contributor.authorKütük N.
dc.contributor.authorCıcık M.F.
dc.contributor.authorBilge S.
dc.contributor.authorAkçay H.
dc.contributor.authorSaygılı S.
dc.contributor.authorTuğlu M.İ.
dc.contributor.authorAlkan A.
dc.date.accessioned2024-07-22T08:09:28Z
dc.date.available2024-07-22T08:09:28Z
dc.date.issued2018
dc.description.abstractPurpose: Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA). Materials and methods: Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3. Results: The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05). Conclusion: Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10006-018-0729-3
dc.identifier.issn18651550
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14840
dc.language.isoEnglish
dc.publisherSpringer Verlag
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectBone Substitutes
dc.subjectBone Transplantation
dc.subjectBoric Acids
dc.subjectMale
dc.subjectMaxillary Sinus
dc.subjectOsteogenesis
dc.subjectRabbits
dc.subjectSinus Floor Augmentation
dc.subjectboric acid
dc.subjectadministration and dosage
dc.subjectanatomy and histology
dc.subjectanimal
dc.subjectbone development
dc.subjectbone prosthesis
dc.subjectbone transplantation
dc.subjectdrug effect
dc.subjectdrug therapy
dc.subjectLeporidae
dc.subjectmale
dc.subjectmaxillary sinus
dc.subjectoral drug administration
dc.subjectprocedures
dc.subjectsinus floor augmentation
dc.subjectsurgery
dc.titleEffects of boric acid on bone formation after maxillary sinus floor augmentation in rabbits
dc.typeArticle

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