Fat-free milk as a therapeutic approach for constipation and the effect on serum motilin and ghrelin levels

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dc.contributor.authorAydin S.
dc.contributor.authorDonder E.
dc.contributor.authorAkin O.K.
dc.contributor.authorSahpaz F.
dc.contributor.authorKendir Y.
dc.contributor.authorAlnema M.M.
dc.date.accessioned2024-07-22T08:20:50Z
dc.date.available2024-07-22T08:20:50Z
dc.date.issued2010
dc.description.abstractObjective: This study explores the effects of fat-free milk supplementation on individuals with chronic constipation with regard to levels of motilin and acylated and des-acylated ghrelin (which affect intestinal motility) and compares them with data from control subjects given whole milk supplementation. Methods: The investigation was designed according to the constipation severity test of individuals whose ages and body mass indexes were comparable. Individuals with mild constipation (n=10) were supplemented with 400. mL of fat-free milk daily; moderate constipation cases (n=10) were supplemented with 600 mL, and severe constipation cases (n=10) were supplemented with 800 mL of fat-free milk daily. Healthy control subjects were administered 400 mL of fat-free milk (group 1), which was followed a month later by administration of 400 mL of whole milk for 3 days (group 2). Blood samples were collected from the subjects before and after milk supplementation for hormone analyses. Motilin and acylated and des-acylated ghrelin were quantified with ELISA assay. Results: Supplementation of fat-free milk significantly increased levels of circulating motilin and ghrelin in all groups, including the control subjects, but whole milk supplementation led to a decrease in these hormone levels in the control subjects. Conclusion: Drinking fat-free milk might be a new way of solving constipation. © 2010 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.nut.2009.11.023
dc.identifier.issn08999007
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18346
dc.language.isoEnglish
dc.subjectAcylation
dc.subjectAdult
dc.subjectAged
dc.subjectAnimals
dc.subjectBiological Products
dc.subjectCase-Control Studies
dc.subjectChronic Disease
dc.subjectConstipation
dc.subjectDietary Fats
dc.subjectDietary Supplements
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectGastrointestinal Motility
dc.subjectGhrelin
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMilk
dc.subjectMotilin
dc.subjectSeverity of Illness Index
dc.subjectghrelin
dc.subjectmotilin
dc.subjectacylation
dc.subjectadult
dc.subjectarticle
dc.subjectchronic disease
dc.subjectclinical article
dc.subjectclinical effectiveness
dc.subjectconstipation
dc.subjectcontrolled study
dc.subjectdeacylation
dc.subjectdiet supplementation
dc.subjectdiet therapy
dc.subjectdisease severity
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthormone determination
dc.subjecthuman
dc.subjectintestine motility
dc.subjectmale
dc.subjectmilk
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectquantitative analysis
dc.subjecttreatment response
dc.titleFat-free milk as a therapeutic approach for constipation and the effect on serum motilin and ghrelin levels
dc.typeArticle

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