Role of proopiomelanocortin in preventing miscarriage

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dc.contributor.authorOzbilgin K.
dc.contributor.authorKahraman B.
dc.contributor.authorAtay C.
dc.contributor.authorVatansever S.
dc.contributor.authorUluer E.T.
dc.contributor.authorÖzçakır T.
dc.date.accessioned2024-07-22T08:10:49Z
dc.date.available2024-07-22T08:10:49Z
dc.date.issued2017
dc.description.abstractOBJECTIVE: To compare the distribution of proopiomelanocortin (POMC) in decidua and placenta samples from missed abortion and voluntary termination cases in order to research the effects in the etiology of missed abortion. STUDY DESIGN: Decidual materials were collected from patients who were diagnosed with missed abortion (n=19) and legal voluntary termination cases (n=15) under 10 gestational weeks. Materials were divided into 2 groups for examination. For all samples, POMC primary anti body was performed by immunohistochemical staining. The number of stained cells was calculated by using the Hscore technique. RESULTS: In the missed abortion group the mean age was 28.7 (18–41), and in the control group the mean age was 27.5 (21–37). POMC immunoreactivity was determined to be lower in the parenchyma and placenta of the missed abortion group than those of the control group. POMC immunoreactivities were found to be higher in both the syncytiotrophoblast and cytotrophoblast cells of the missed abortion group than those of the control group (p<0.005). CONCLUSION: POMC has become a paradigmatic polypeptide precursor and has a role in the parturition process. Local production of POMC in placenta and decidua may influence pregnancy and may have a role in missed abortion pathogenesis. © Journal of Reproductive Medicine®, Inc.
dc.identifier.issn00247758
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15376
dc.language.isoEnglish
dc.publisherJournal of Reproductive Medicine, Inc.
dc.subjectproopiomelanocortin
dc.subjectadult
dc.subjectArticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytotrophoblast
dc.subjectdecidua
dc.subjectfemale
dc.subjectgestational age
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmissed abortion
dc.subjectpriority journal
dc.subjectspontaneous abortion
dc.subjectsyncytiotrophoblast
dc.titleRole of proopiomelanocortin in preventing miscarriage
dc.typeArticle

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