Does asthma control as assessed by the asthma control test reflect airway inflammation?

Simple item page
dc.contributor.authorBora M.
dc.contributor.authorAlpaydin A.O.
dc.contributor.authorYorgancioglu A.
dc.contributor.authorAkkas G.
dc.contributor.authorIsisag A.
dc.contributor.authorCoskun A.S.
dc.contributor.authorCelik P.
dc.date.accessioned2024-07-22T08:20:00Z
dc.date.available2024-07-22T08:20:00Z
dc.date.issued2011
dc.description.abstractBackground and aims: The treatment of asthmatic patients is particularly focused on the control of symptoms as well as functional and inflammatory parameters. In our study, we investigated the relationship between the asthma control test (ACT) which evaluates symptoms and airway inflammation and functional parameters. Materials and methods: Stable asthmatic patients admitted to our pulmonary outpatient clinic were enrolled in the study consecutively and underwent the ACT, pulmonary function tests and methacholine bronchial provocation test (MBPT). Additionally, fractional exhaled nitric oxide level (FeNO) and induced sputum cell distribution were assessed. All these parameters were re-evaluated at the third month after adjusting medications of the patients according to baseline ACT scores. Results: Of the 101 patients screened, we analyzed 83 who proceeded to the follow up visit. At the baseline visit, 8 were totally controlled, 36 partially controlled and 39 uncontrolled according to ACT. At the follow up visit, 10 were totally controlled, 39 partially controlled and 34 uncontrolled. Comparison of the two visits in terms of all parameters revealed significant reductions only in the percentages of patients with MBPT positivity (p = 0.029) and FeNO levels > 20 ppb (p = 0.025) at follow up. The percentages of patients with FeNO > 20 ppb, MBPT positivity, induced sputum eosinophilia or induced sputum neutrophilia did not show significant differences between totally controlled, partially controlled and uncontrolled groups at both baseline and follow up visits. Conclusion: Although the ACT scores did not show significant correlations with the airway inflammation parameters tested in this study, a marked reduction in the percentage of patients with MBPT positivity and FeNO > 20 ppb at follow up may suggest the importance of the control concept in the management of asthma.
dc.identifier.DOI-ID10.1186/2049-6958-6-5-291
dc.identifier.issn1828695X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17957
dc.language.isoEnglish
dc.publisherBioMed Central Ltd.
dc.rightsAll Open Access; Gold Open Access
dc.subjectmethacholine
dc.subjectnitric oxide
dc.subjectadult
dc.subjectarticle
dc.subjectasthma
dc.subjectasthma control test
dc.subjectcellular distribution
dc.subjectclinical assessment tool
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectdisease control
dc.subjectfemale
dc.subjecthospital admission
dc.subjecthuman
dc.subjectinhalation test
dc.subjectlung function test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneutrophilia
dc.subjectoutpatient
dc.subjectprovocation test
dc.subjectrespiratory tract inflammation
dc.subjectsputum
dc.titleDoes asthma control as assessed by the asthma control test reflect airway inflammation?
dc.typeArticle

Files

Collections

Scopus Koleksiyonu