Prevalence of prostate cancer in high boron-exposed population: A community-based study

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dc.contributor.authorMüezzinoğlu T.
dc.contributor.authorKorkmaz M.
dc.contributor.authorNeşe N.
dc.contributor.authorBakırdere S.
dc.contributor.authorArslan Y.
dc.contributor.authorAtaman O.Y.
dc.contributor.authorLekili M.
dc.date.accessioned2024-07-22T08:20:26Z
dc.date.available2024-07-22T08:20:26Z
dc.date.issued2011
dc.description.abstractWe investigated the possible relationship between boron exposure and prostate cancer (PCa) for men living and being employed at boron mines in villages with rich boron minerals. Out of 456 men studied, 159 were from villages with rich boron sources and boron levels in drinking water of >1 mg L -1 and these men formed the study group, while 63 from villages with rich boron sources and boron levels in drinking water of <1 mg L -1 were enrolled into control group 1. A further 234 subjects from other villages with no boron mines were considered as control group 2. Prostate specific antigen (PSA) levels could be obtained from a total of 423 men. Urinary boron concentration as an indicator of boron exposure in 63 subjects, prostatic volumes by transrectal ultrasonography in 39 subjects, and prostatic biopsies in 36 subjects were obtained for study and control groups. The daily boron exposure was calculated according to urinary boron levels. Although there was no significant difference among the groups in terms of total PSA levels, the number of subjects with tPSA ≥2.5 and tPSA ≥10.0 ng dL -1 prostatic volumes in men whose prostates were biopsied (p<0.012) was significantly lower in the study group as compared with those in the control group 2. These results suggested that high exposure to boron might have an implication within the prostatic cellular processes related to hyperplasia and carcinogenesis, even though we did not find a statistically significant association between PCa and boron exposure. © Springer Science+Business Media, LLC 2011.
dc.identifier.DOI-ID10.1007/s12011-011-9023-z
dc.identifier.issn01634984
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18161
dc.language.isoEnglish
dc.publisherHumana Press Inc.
dc.subjectboron
dc.subjectcreatinine
dc.subjectdrinking water
dc.subjectprostate specific antigen
dc.subjectadult
dc.subjectarticle
dc.subjectboron urine level
dc.subjectcancer localization
dc.subjectcarcinogenesis
dc.subjectcommunity living
dc.subjectcontrolled study
dc.subjectcreatinine clearance
dc.subjectdisease association
dc.subjectdisease marker
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmining
dc.subjectmolecular pathology
dc.subjectoccupational exposure
dc.subjectprostate biopsy
dc.subjectprostate cancer
dc.subjectprostate hypertrophy
dc.subjecttransrectal ultrasonography
dc.subjecturine level
dc.subjectwater contamination
dc.titlePrevalence of prostate cancer in high boron-exposed population: A community-based study
dc.typeArticle

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