Social approach and avoidance behaviour for negative emotions is modulated by endogenous oxytocin and paranoia in schizophrenia

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dc.contributor.authorBrown E.C.
dc.contributor.authorTas C.
dc.contributor.authorKuzu D.
dc.contributor.authorEsen-Danaci A.
dc.contributor.authorRoelofs K.
dc.contributor.authorBrüne M.
dc.date.accessioned2024-07-22T08:14:31Z
dc.date.available2024-07-22T08:14:31Z
dc.date.issued2014
dc.description.abstractPatients with schizophrenia suffer from dysfunctional social behaviour. Social approach and avoidance (AA) has been associated with motor responses, as the affective valence and gaze direction of facial stimuli can bias push and pull motor tendencies. The aim of this study was to investigate the role of endogenous oxytocin in social AA behaviour in schizophrenia. Basal plasma oxytocin levels were collected from 28 patients who were then given a joystick-based Approach-Avoidance Task (AAT). Reaction times were recorded and AAT effect scores calculated for responses to happy and angry faces, which either had direct or averted gaze. Individual differences in basal oxytocin had a significant relationship with AAT responses, and patients with higher levels of oxytocin tended to avoid angry faces more. Furthermore, greater avoidance of angry faces was correlated with more severe psychotic (positive and general) symptoms and greater paranoia. This suggests that the endogenous effects of oxytocin may be specific to the interpretation of negative threatening emotions in schizophrenia patients, and also provides evidence that psychotic symptoms and paranoia can impact on social AA behaviour by heightening threat avoidance. © 2014 Elsevier Ireland Ltd.
dc.identifier.DOI-ID10.1016/j.psychres.2014.06.038
dc.identifier.issn01651781
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16599
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectAdult
dc.subjectAnger
dc.subjectAvoidance Learning
dc.subjectBehavior
dc.subjectEmotions
dc.subjectFacial Expression
dc.subjectFemale
dc.subjectHappiness
dc.subjectHumans
dc.subjectLearning
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectOxytocics
dc.subjectOxytocin
dc.subjectParanoid Disorders
dc.subjectPersonality Disorders
dc.subjectQuestionnaires
dc.subjectReaction Time
dc.subjectRecognition (Psychology)
dc.subjectSchizophrenia
dc.subjectSocial Behavior
dc.subjectTask Performance and Analysis
dc.subjectYoung Adult
dc.subjectoxytocin
dc.subjectoxytocic agent
dc.subjectoxytocin
dc.subjectadult
dc.subjectapproach avoidance task
dc.subjectarticle
dc.subjectavoidance behavior
dc.subjectclinical article
dc.subjectdisease severity
dc.subjectemotion
dc.subjectfacial expression
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectoxytocin blood level
dc.subjectparanoia
dc.subjectpriority journal
dc.subjectpsychosis
dc.subjectresponse time
dc.subjectschizophrenia
dc.subjectscoring system
dc.subjectsocial behavior
dc.subjecttask performance
dc.subjectanger
dc.subjectavoidance behavior
dc.subjectbehavior
dc.subjectblood
dc.subjectdrug effects
dc.subjectemotion
dc.subjecthappiness
dc.subjectlearning
dc.subjectmiddle aged
dc.subjectneuropsychological test
dc.subjectparanoid psychosis
dc.subjectpersonality disorder
dc.subjectphysiology
dc.subjectquestionnaire
dc.subjectreaction time
dc.subjectrecognition
dc.subjectschizophrenia
dc.subjectyoung adult
dc.titleSocial approach and avoidance behaviour for negative emotions is modulated by endogenous oxytocin and paranoia in schizophrenia
dc.typeArticle

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