Factors affecting long-term renal functions after partial vs radical nephrectomy for clinical T1 renal masses: A Multicentre Study of the Urooncology Association, Turkey

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dc.contributor.authorIzol V.
dc.contributor.authorGokalp F.
dc.contributor.authorSozen S.
dc.contributor.authorOzden E.
dc.contributor.authorBayazit Y.
dc.contributor.authorMuezzinoglu T.
dc.contributor.authorKara O.
dc.contributor.authorCetin S.
dc.contributor.authorGulsen M.
dc.contributor.authorTurkeri L.
dc.contributor.authorZuhtu Tansug M.
dc.date.accessioned2024-07-22T08:05:57Z
dc.date.available2024-07-22T08:05:57Z
dc.date.issued2021
dc.description.abstractPurpose: To compare the functional outcomes of patients who underwent partial (PN) or radical nephrectomy (RN) for clinical T1 (cT1) renal tumours using the Kidney Cancer Database of the Urooncology Association, Turkey. Methods: We retrospectively reviewed 1004 patients who underwent PN and RN for cT1 renal tumours at multiple academic tertiary centres between 2000 and 2018. Patients with preoperative end-stage chronic kidney disease and/or metastatic disease were excluded. Results: There were 452 patients in the PN group and 552 patients in the RN group. The median follow-ups were 74.9 and 83.7 months in RN and PN cohort. The eGFR was significantly reduced in both groups on postoperative day 1 (PN = 13.7 vs RN = 19.1 mL/min/1.73 m2: P <.001). In the PN group, eGFR showed a tendency to recover according to a quadratic pattern and reached preoperative levels in the first and third years (95.6 ± 28.8 mL/min/1.73 m2 and 96.9 ± 28.9 mL/min/1.73 m2, respectively), with no significant difference between the eGFRs in the 1st and 3rd years (P =.710). To define groups at risk, different cut-off values for the GFR were considered. Among patients with a baseline GFR < 90, the RN cohort had significantly lower eGFRs in the first and third years than the PN cohort (P =.02). Logistic regression showed that comorbidities, coronary artery disease, diabetes and hypertension had no adverse impacts on the changes in the eGFR (P =.60, P =.13, and P =.13, respectively). Conclusion: For the treatment of stage T1 kidney tumours, open or laparoscopic partial nephrectomy has the benefit to preserve renal function. © 2021 John Wiley & Sons Ltd
dc.identifier.DOI-ID10.1111/ijcp.13960
dc.identifier.issn13685031
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13319
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectCarcinoma, Renal Cell
dc.subjectGlomerular Filtration Rate
dc.subjectHumans
dc.subjectKidney Neoplasms
dc.subjectNephrectomy
dc.subjectRetrospective Studies
dc.subjectTurkey
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectblood transfusion
dc.subjectclinical outcome
dc.subjectcohort analysis
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectdiabetes mellitus
dc.subjectestimated glomerular filtration rate
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthypertension
dc.subjectkidney function
dc.subjectkidney tumor
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectoperative blood loss
dc.subjectoverall survival
dc.subjectpartial nephrectomy
dc.subjectperoperative complication
dc.subjectpostoperative complication
dc.subjectpredictor variable
dc.subjectpriority journal
dc.subjectradical nephrectomy
dc.subjectretrospective study
dc.subjectsurvival time
dc.subjecttumor volume
dc.subjectTurkey (republic)
dc.subjectadverse event
dc.subjectclinical trial
dc.subjectepidemiology
dc.subjectglomerulus filtration rate
dc.subjectmulticenter study
dc.subjectnephrectomy
dc.subjectrenal cell carcinoma
dc.subjectturkey (bird)
dc.titleFactors affecting long-term renal functions after partial vs radical nephrectomy for clinical T1 renal masses: A Multicentre Study of the Urooncology Association, Turkey
dc.typeArticle

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