Ovarian failure in diabetic rat model: Nuclear factor-kappaB, oxidative stress, and pentraxin-3

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dc.contributor.authorErbas O.
dc.contributor.authorPala H.G.
dc.contributor.authorPala E.E.
dc.contributor.authorOltulu F.
dc.contributor.authorAktug H.
dc.contributor.authorYavasoglu A.
dc.contributor.authorTaskiran D.
dc.date.accessioned2024-07-22T08:14:47Z
dc.date.available2024-07-22T08:14:47Z
dc.date.issued2014
dc.description.abstractObjective: The aim of the present study was to investigate the effects of diabetes mellitus (DM) on ovarian reserve and injury by considering laboratory and histopathological parameters in rat models. Materials and methods: An experimental DM model was created in 16 rats. Eight rats with normal blood glucose levels were included in the control group. Diabetic rats were divided randomly into two groups: nontreated and resveratrol-treated groups. Histopathological examination and nuclear factor (NF)-κB immunoexpression level determination were performed. Plasma malondialdehyde, glutathione, pentraxin-3, and anti-Müllerian hormone levels were measured. Relations between the variables were compared by Student t test, analysis of variance, and Mann-Whitney U and χ2 tests. Results: We found statistically significantly lower glutathione and anti-Müllerian hormone levels, and higher malondialdehyde and pentraxin-3 levels in nontreated diabetic group when compared with the control and resveratrol-treated diabetic groups. Stromal degeneration, follicle degeneration, stromal fibrosis scores, and NF-κB immunoexpression levels were significantly higher in nontreated diabetic rats. Primordial and primary follicle counts were significantly lower in the nontreated diabetic group when compared with the control and resveratrol-treated groups. There was no statistically significant difference in secondary and tertiary follicles between these groups. Conclusion: These findings provide strong evidence that the ovarian follicle pool in nontreated diabetic rats is affected in the early stages of the follicle development process. We precluded negative effects of DM on ovaries by inhibiting the NF-κB pathway with resveratrol. We thought that the NF-κB pathway plays a role in the pathophysiology of ovarian failure in diabetic rats. Further studies should evaluate this precise mechanism that leads to a decline in the anti-Müllerian hormone levels. In addition, the relationship between this abnormality and reproductive function in diabetic patients should be analyzed further. © 2014.
dc.identifier.DOI-ID10.1016/j.tjog.2013.11.008
dc.identifier.issn10284559
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16654
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectC-Reactive Protein
dc.subjectDiabetes Mellitus, Experimental
dc.subjectFemale
dc.subjectNF-kappa B
dc.subjectOvarian Reserve
dc.subjectOvary
dc.subjectOxidative Stress
dc.subjectPrimary Ovarian Insufficiency
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSerum Amyloid P-Component
dc.subjectStilbenes
dc.subjectglutathione
dc.subjectmalonaldehyde
dc.subjectMuellerian inhibiting factor
dc.subjectpentraxin 3
dc.subjectreceptor activator of nuclear factor kappa B
dc.subjectresveratrol
dc.subjectantioxidant
dc.subjectC reactive protein
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectpentraxin 3
dc.subjectserum amyloid P
dc.subjectstilbene derivative
dc.subjectanalysis of variance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdiabetic patient
dc.subjectenzyme blood level
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthistopathology
dc.subjecthormone blood level
dc.subjectnonhuman
dc.subjectovary follicle
dc.subjectovary follicle development
dc.subjectovary insufficiency
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectprotein expression
dc.subjectrat
dc.subjectreproduction
dc.subjectscoring system
dc.subjectStudent t test
dc.subjectanimal
dc.subjectantagonists and inhibitors
dc.subjectcomplication
dc.subjectDiabetes Mellitus, Experimental
dc.subjectevaluation study
dc.subjectmetabolism
dc.subjectovarian reserve
dc.subjectovary
dc.subjectpathology
dc.subjectPrimary Ovarian Insufficiency
dc.subjectrandomization
dc.subjectSprague Dawley rat
dc.titleOvarian failure in diabetic rat model: Nuclear factor-kappaB, oxidative stress, and pentraxin-3
dc.typeArticle

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