Increased vitamin D binding protein levels are associated with irritable bowel syndrome; [Artmis D vitamini baglayici protein seviyeleri Irritabl barsak sendromu ile iliskilidir]

Simple item page
dc.contributor.authorBörekci E.
dc.contributor.authorKili M.
dc.contributor.authorOzan Z.
dc.contributor.authorBörekci H.
dc.contributor.authorYildirim T.
dc.contributor.authorGöçmen Y.
dc.contributor.authorBas H.
dc.date.accessioned2024-07-22T08:05:36Z
dc.date.available2024-07-22T08:05:36Z
dc.date.issued2021
dc.description.abstractObjectives: There is no reliable and valid biomarker to identify Irritable bowel syndrome (IBS) and its subtypes. The aim of this study is to explore potential serum biomarkers that may be associated with IBS subtypes, particularly in the vitamin D pathway. Methods: The study population comprised 75 IBS patients and 79 controls. Patients divided into IBS subtypes. Routine biochemical parameters, 25-OH-vitamin D, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) serum levels were compared between IBS subtypes and controls. Factors related to IBS subtypes were examined by multivariate logistic regression analysis. Results: Vitamin D levels were lower; VDBP and VDR were higher in all IBS patients than in controls (p<0.001; 0.047 and 0.029, respectively). According to logistic regression analysis, VDBP was a disease-related parameter as much as vitamin D in all IBS subtypes. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were higher especially in diarrhea-dominant IBS (IBS-D) (p=0.041; 0.046) and vitamin B12 were significantly lower in constipation-dominant IBS (IBS-C) (p=0.001). Conclusions: Increased VDBP levels were associated with all IBS subtypes. Patients, especially in IBS-D, had higher serum levels of VDBP, CRP and ESR. Vitamin B12 deficiency, which we consider as a result of the disease, was more common in IBS-C Open Access. 2021 Elif B rekci et al. © 2021 De Gruyter. All rights reserved.
dc.identifier.DOI-ID10.1515/TJB-2020-0305
dc.identifier.issn02504685
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13185
dc.language.isoEnglish
dc.publisherDe Gruyter Open Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subject25 hydroxyvitamin D
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectbiochemical marker
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectcreatinine
dc.subjectlow density lipoprotein cholesterol
dc.subjectthyrotropin
dc.subjectvitamin D binding protein
dc.subjectvitamin D receptor
dc.subjectadult
dc.subjectalanine aminotransferase blood level
dc.subjectArticle
dc.subjectB12 deficiency
dc.subjectbody mass
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdiagnostic test accuracy study
dc.subjectdiarrhea
dc.subjecterythrocyte sedimentation rate
dc.subjectfemale
dc.subjectgene expression
dc.subjecthematocrit
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectirritable colon
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectplatelet count
dc.subjectprotein blood level
dc.subjectprotein expression
dc.subjectvitamin blood level
dc.subjectvitamin D deficiency
dc.titleIncreased vitamin D binding protein levels are associated with irritable bowel syndrome; [Artmis D vitamini baglayici protein seviyeleri Irritabl barsak sendromu ile iliskilidir]
dc.typeArticle

Files

Collections

Scopus Koleksiyonu