Investigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage

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dc.contributor.authorAydemir I.
dc.contributor.authorÖzbey C.
dc.contributor.authorÖzkan O.
dc.contributor.authorKum Ş.
dc.contributor.authorTuğlu M.İ.
dc.date.accessioned2024-07-22T08:07:19Z
dc.date.available2024-07-22T08:07:19Z
dc.date.issued2020
dc.description.abstractBisphenol-A (BPA) used in the production of plastic materials is a temperature-soluble agent. It also has a steroid hormone-like activity; therefore, it poses a danger to human health. In our study, we aimed to investigate the effects of BPA on lymph node and spleen in male rats exposed to this agent during prenatal stage. The pregnant female rats were divided into four groups: control, sham, low dose (300 µg/kg BPA), and high dose (900 µg/kg BPA). BPA was dissolved in 1 mL of corn oil and administered to the pregnant rats every day during pregnancy. On the 21st and 45th day after the birth, male rats’ lymph node and spleen samples were taken and histopathological examination was performed. Samples were stained with hematoxylin and eosin to determine the general histological appearance, and with CD3 and CD20 immunohistochemically. The results of staining were evaluated by H-score, and statistical analysis was performed. In the samples, BPA applications were not found to cause significant tissue damage. But there was a significant decrease in the immunoreactivities of CD3 and CD20 after BPA applications in both 21st and 45th day samples. After high dose BPA administration, decreased CD3 immunoreactivity was statistically significant. It is thought that BPA does not cause histologically significant tissue damage, but it may impair organ function at cellular level. The investigation of molecules involved in organ function will be useful in revealing the mechanisms that will cause dysfunction. © The Author(s) 2020.
dc.identifier.DOI-ID10.1177/0748233720941759
dc.identifier.issn07482337
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13927
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBenzhydryl Compounds
dc.subjectEndocrine Disruptors
dc.subjectFemale
dc.subjectLymph Nodes
dc.subjectMale
dc.subjectPhenols
dc.subjectPregnancy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSpleen
dc.subjectToxicity Tests
dc.subject4,4' isopropylidenediphenol
dc.subjectCD200 antigen
dc.subjectCD3 antigen
dc.subject4,4' isopropylidenediphenol
dc.subjectbenzhydryl derivative
dc.subjectendocrine disruptor
dc.subjectphenol derivative
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthistology
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectlymph node
dc.subjectlymphatic system
dc.subjectlymphocytotoxicity
dc.subjectmultiple organ failure
dc.subjectnonhuman
dc.subjectprenatal exposure
dc.subjectrat
dc.subjectspleen tissue
dc.subjectstatistical analysis
dc.subjecttissue injury
dc.subjectanimal
dc.subjectdrug effect
dc.subjectlymph node
dc.subjectmale
dc.subjectmetabolism
dc.subjectnewborn
dc.subjectpregnancy
dc.subjectprenatal exposure
dc.subjectspleen
dc.subjecttoxicity testing
dc.subjectWistar rat
dc.titleInvestigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage
dc.typeArticle

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