Relationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population

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dc.contributor.authorOrenay-Boyacioglu S.
dc.contributor.authorCoskunoglu A.
dc.contributor.authorCaki Z.
dc.contributor.authorCam F.S.
dc.date.accessioned2024-07-22T08:11:39Z
dc.date.available2024-07-22T08:11:39Z
dc.date.issued2016
dc.description.abstractGlial cell line-derived neurotrophic factor (GDNF) plays a key role in early development of central auditory pathway and the inner ear. However, the auditory pathway studies of GDNF gene polymorphisms are scarce in the literature, and the studies especially associated with tinnitus are limited. Our study aimed to identify whether GDNF gene polymorphisms play any roles in the pathophysiology of tinnitus by investigating the relationship between tinnitus and GDNF polymorphisms. A total of 52 patients with chronic tinnitus and ages ranging from 18 to 55 were admitted to the Ear–Nose–Throat outpatient clinic of Celal Bayar University Medical Faculty Hospital of Manisa, Turkey and constituted the study group. Another 42 patients of the same age range, without tinnitus symptoms and lacking any systemic disease, were also admitted to the clinic and formed the control group. The tympanometric, audiological, and psychoacoustic assessments of the subjects were performed. Deoxyribonucleic acid samples obtained using venous blood taken for routine inspections were used to investigate GDNF gene polymorphisms (rs884344, rs3812047, and rs1110149) by polymerase chain reaction-based restriction fragment length polymorphism method. No correlation could be detected between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus (p > 0.05). Heterozygosity was significantly lower for GDNF rs1110149 polymorphism in tinnitus subjects compared to the controls (p < 0.05). However, the allele frequencies for all 3 polymorphisms were not significantly different between tinnitus and control groups (p > 0.05). Failure to detect correlations between tinnitus and GDNF gene polymorphisms suggests this may be due to the fact that the GDNF gene has a variable expression pattern in different tissues and pathologies. Therefore, the study should be improved and its scope should be expanded by including a larger group of patients and different tissues to investigate the expression pattern of GDNF. © 2016, Springer Science+Business Media New York.
dc.identifier.DOI-ID10.1007/s10528-016-9741-1
dc.identifier.issn00062928
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15741
dc.language.isoEnglish
dc.publisherSpringer New York LLC
dc.subjectAdult
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectGlial Cell Line-Derived Neurotrophic Factor
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectTinnitus
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectneurotrophic factor
dc.subjectGDNF protein, human
dc.subjectglial cell line derived neurotrophic factor
dc.subjectadult
dc.subjectArticle
dc.subjectaudiology
dc.subjectchronic disease
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene
dc.subjectgene expression
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectglia cell
dc.subjectheterozygosity
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmolecular pathology
dc.subjectpolymerase chain reaction
dc.subjectpsychophysics
dc.subjectrestriction fragment length polymorphism
dc.subjecttinnitus
dc.subjectTurk (people)
dc.subjecttympanometry
dc.subjectCaucasian
dc.subjectgenetic association study
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectmiddle aged
dc.subjectsingle nucleotide polymorphism
dc.subjecttinnitus
dc.subjectTurkey
dc.subjectyoung adult
dc.titleRelationship Between Chronic Tinnitus and Glial Cell Line-Derived Neurotrophic Factor Gene rs3812047, rs1110149, and rs884344 Polymorphisms in a Turkish Population
dc.typeArticle

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