Ketoprofen gel improves low back pain in addition to IV dexketoprofen: a randomized placebo-controlled trial

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dc.contributor.authorSerinken M.
dc.contributor.authorEken C.
dc.contributor.authorTunay K.
dc.contributor.authorGolcuk Y.
dc.date.accessioned2024-07-22T08:11:32Z
dc.date.available2024-07-22T08:11:32Z
dc.date.issued2016
dc.description.abstractObjective Oligoanalgesia is common in emergency departments (EDs), and pain management is of concern for ED physicians. The aim of this study was to reveal the effect of ketoprofen gel in patients presenting with mechanical low back pain to the ED. Method All the study patients received intravenous dexketoprofen additional to study drugs. After dexketoprofen, 2 g of 2.5% ketoprofen gel or placebo was administered to the site with pain and tenderness. Pain relief at 15 and 30 minutes was measured by visual analog scale scores. Rescue drug need and adverse effects were also recorded. Results A total of 140 patients were enrolled into the study. The mean age of the study patients was 35 ± 12, and 56% (n = 79) of them were male. The mean pain reduction at 30 minutes was 52 ± 18 for ketoprofen gel and 37 ± 17 for placebo, and ketoprofen gel was better than placebo at 30 minutes (mean difference, 16 mm; 95% confidence interval, 10-21). Ten patients (14%) in the placebo group and 2 patients (3%) in the ketoprofen gel group needed rescue drug (P = .35). Conclusion Ketoprofen gel improves pain in patients presenting with mechanical low back pain to ED at 30 minutes in addition to intravenous dexketoprofen when compared to placebo. © 2016 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.ajem.2016.04.028
dc.identifier.issn07356757
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15678
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDouble-Blind Method
dc.subjectDrug Therapy, Combination
dc.subjectEmergency Service, Hospital
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectInjections, Intravenous
dc.subjectKetoprofen
dc.subjectLow Back Pain
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPain Measurement
dc.subjectProspective Studies
dc.subjectTreatment Outcome
dc.subjectTromethamine
dc.subjectYoung Adult
dc.subjectdexketoprofen
dc.subjectketoprofen
dc.subjectplacebo
dc.subjectdexketoprofen
dc.subjectketoprofen
dc.subjectketoprofen topical gel
dc.subjectnonsteroid antiinflammatory agent
dc.subjecttrometamol
dc.subjectadult
dc.subjectanalgesia
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthuman
dc.subjectlow back pain
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectvisual analog scale
dc.subjectadolescent
dc.subjectaged
dc.subjectanalogs and derivatives
dc.subjectclinical trial
dc.subjectcombination drug therapy
dc.subjectfollow up
dc.subjecthospital emergency service
dc.subjectintravenous drug administration
dc.subjectlow back pain
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectpain measurement
dc.subjecttreatment outcome
dc.subjectyoung adult
dc.titleKetoprofen gel improves low back pain in addition to IV dexketoprofen: a randomized placebo-controlled trial
dc.typeArticle

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