Effects of sex and age on regional prefrontal brain volume in two human cohorts

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dc.contributor.authorCowell P.E.
dc.contributor.authorSluming V.A.
dc.contributor.authorWilkinson I.D.
dc.contributor.authorCezayirli E.
dc.contributor.authorRomanowski C.A.J.
dc.contributor.authorWebb J.A.
dc.contributor.authorKeller S.S.
dc.contributor.authorMayes A.
dc.contributor.authorRoberts N.
dc.date.accessioned2024-07-22T08:23:10Z
dc.date.available2024-07-22T08:23:10Z
dc.date.issued2007
dc.description.abstractThis study examined interactive effects of sex and age on prefrontal brain anatomy in humans. It specifically targeted ranges of the adult life span and regions of cortex that previously showed male-female differences. Participants were 68 healthy human males and females aged 20-72 years. Data collection and analysis were conducted in parallel across two cohorts (laboratories) to investigate reproducibility of effects in relation to sex and age. Volumes for four regional prefrontal subfields per hemisphere were obtained from high-resolution MRI. Regional sex by age interactions were replicated across cohorts. In men, age effects were greatest in medial prefrontal volume, with decreases in dorsal medial and orbital medial regions. In women, age-related changes in medial prefrontal regions were limited to the dorsal volume, with additional decreases observed in lateral subfields. Cohort and Cohort x Age effects in total brain and total prefrontal volume were linked to a combination of methodological and sampling-related factors. Findings indicated that neuroanatomical changes throughout adulthood unfold along different time scales in men and women. Results also showed that sex differences in ageing localized to medial prefrontal regions were particularly robust to variation across cohorts. © The Authors (2007).
dc.identifier.DOI-ID10.1111/j.1460-9568.2006.05281.x
dc.identifier.issn14609568
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19409
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectAging
dc.subjectBrain Mapping
dc.subjectCohort Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectImage Processing, Computer-Assisted
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrefrontal Cortex
dc.subjectSex Characteristics
dc.subjectSex Factors
dc.subjectadult
dc.subjectage distribution
dc.subjectaged
dc.subjectarticle
dc.subjectbrain region
dc.subjectbrain size
dc.subjectcohort analysis
dc.subjectfemale
dc.subjecthemisphere
dc.subjecthuman
dc.subjectimage quality
dc.subjectlifespan
dc.subjectmale
dc.subjectneuroanatomy
dc.subjectnormal human
dc.subjectnuclear magnetic resonance imaging
dc.subjectprefrontal cortex
dc.subjectpriority journal
dc.subjectreproducibility
dc.subjectsex difference
dc.titleEffects of sex and age on regional prefrontal brain volume in two human cohorts
dc.typeArticle

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