Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)

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dc.contributor.authorInal A.
dc.contributor.authorKodaz H.
dc.contributor.authorOdabas H.
dc.contributor.authorDuran A.
dc.contributor.authorSeker M.
dc.contributor.authorInanc M.
dc.contributor.authorElkiran E.
dc.contributor.authorGunaydin Y.
dc.contributor.authorMenekse S.
dc.contributor.authorTopcu T.
dc.contributor.authorUrakci Z.
dc.contributor.authorTastekin D.
dc.contributor.authorBilici M.
dc.contributor.authorCihan S.
dc.contributor.authorGeredeli C.
dc.contributor.authorSezer E.
dc.contributor.authorUncu D.
dc.contributor.authorArpaci E.
dc.contributor.authorOzturk B.
dc.contributor.authorBal O.
dc.contributor.authorUysal M.
dc.contributor.authorTanriverdi O.
dc.contributor.authorGumus M.
dc.contributor.authorOven Ustaalioglu B.
dc.contributor.authorSuner A.
dc.contributor.authorCokmert S.
dc.contributor.authorHacibekiroglu I.
dc.contributor.authorAydin K.
dc.contributor.authorIsikdogan A.
dc.date.accessioned2024-07-22T08:09:58Z
dc.date.available2024-07-22T08:09:58Z
dc.date.issued2018
dc.description.abstractPurpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options. © 2017 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.
dc.identifier.DOI-ID10.4103/0973-1482.176417
dc.identifier.issn09731482
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15031
dc.language.isoEnglish
dc.publisherWolters Kluwer Medknow Publications
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBrain Neoplasms
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCranial Irradiation
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMedical Oncology
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectProportional Hazards Models
dc.subjectTreatment Outcome
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbrain metastasis
dc.subjectcancer chemotherapy
dc.subjectcancer prognosis
dc.subjectcancer radiotherapy
dc.subjectcancer survival
dc.subjectclinical assessment
dc.subjectfemale
dc.subjectfollow up
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectneurosurgery
dc.subjectnon small cell lung cancer
dc.subjectoutcome assessment
dc.subjectoverall survival
dc.subjectretrospective study
dc.subjectskull irradiation
dc.subjectsmoking
dc.subjectTurk (people)
dc.subjectvery elderly
dc.subjectwhole brain radiotherapy
dc.subjectbrain tumor
dc.subjectclinical trial
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectnon small cell lung cancer
dc.subjectoncology
dc.subjectpathology
dc.subjectprognosis
dc.subjectproportional hazards model
dc.subjectskull irradiation
dc.subjecttreatment outcome
dc.subjecttrends
dc.titlePrognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)
dc.typeArticle

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