Calcitonin expression of high endothelial venules during lymphocyte migration in human pharyngeal tonsil

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dc.contributor.authorOzbilgin M.K.
dc.contributor.authorKirmaz C.
dc.contributor.authorYüksel H.
dc.contributor.authorKurtman C.
dc.contributor.authorKaya M.
dc.date.accessioned2024-07-22T08:23:11Z
dc.date.available2024-07-22T08:23:11Z
dc.date.issued2006
dc.description.abstractThe migration routes of lymphocytes through high endothelial venules (HEVs) of control and hypertrophic pharyngeal tonsil (HPT) tissue sections were investigated by immunohistochemistry using the expression of a hormone [calcitonin (CT)] and two calcium-dependent endothelial adhesion molecules (E-selectin and P-selectin), as well as electron microscopy. A marked increase in CT-specific staining was observed in the endothelial cells of HEV in the HPT group compared to the control group. Expressions of E-selectin and P-selectin on HEVs of control group were faint, when compared to the strong expression of these selectins on HEVs of HPT. Electron microscopically, we demonstrated that lymphocytes transmigrated through HEV and observed the close membranous contact between endothelial cells and lymphocytes during this process. We speculate that increasing CT during inflammation may be important for lymphocyte migration through the HEVs via controlling the expression of E-selectin and P-selectin.
dc.identifier.issn00247766
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19422
dc.language.isoEnglish
dc.subjectAdenoids
dc.subjectCalcitonin
dc.subjectCell Movement
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectE-Selectin
dc.subjectEndothelium, Vascular
dc.subjectHumans
dc.subjectHypertrophy
dc.subjectL-Selectin
dc.subjectLymphocytes
dc.subjectVenules
dc.subjectcalcitonin
dc.subjectendothelial leukocyte adhesion molecule 1
dc.subjectPADGEM protein
dc.subjectadenoid
dc.subjectarticle
dc.subjectcell contact
dc.subjectcontrolled study
dc.subjectelectron microscopy
dc.subjectendothelium cell
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectinflammation
dc.subjectlymphocyte migration
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectschool child
dc.subjecttissue section
dc.subjectvenule
dc.titleCalcitonin expression of high endothelial venules during lymphocyte migration in human pharyngeal tonsil
dc.typeArticle

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