Prognostic effects of predominant histologic subtypes in resected pulmonary adenocarcinomas

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dc.contributor.authorYaldız D.
dc.contributor.authorKaya Ş.Ö.
dc.contributor.authorCeylan K.C.
dc.contributor.authorAcar A.
dc.contributor.authorAydoğdu Z.
dc.contributor.authorGürsoy S.
dc.contributor.authorYaldız S.
dc.date.accessioned2024-07-22T08:08:13Z
dc.date.available2024-07-22T08:08:13Z
dc.date.issued2019
dc.description.abstractBackground: Predominant histologic subtypes have been reported as predictors of survival of patients with pulmonary adenocarcinoma. Aims: To evaluate the predictive value of histologic classification in resected lung adenocarcinoma using the classification systems proposed by the International Association for the Study of Lung Cancer, American Thoracic Society, European Respiratory Society, and World Health Organization (2015). Study Design: Cross-sectional study. Methods: The histologic classification of a large cohort of 491 patients with resected lung adenocarcinoma (stages I-III) was retrospectively analyzed. The tumors were classified according to their predominant component (lepidic, acinar, papillary, solid, micropapillary, and mucinous), and their predictive values were assessed for clinicopathologic characteristics and overall survival. Results: The patient cohort comprised 158 (32.2%) patients with solid predominant, 150 (30.5%) with acinar predominant, 80 (16.3%) with papillary predominant, 75 (15.3%) with lepidic predominant, 22 (4.5%) with mucinous, and 5 (1.0%) with micropapillary subtype, and 1 (0.2%) with adenocarcinoma in situ. Overall 5-year survival of 491 patients was found to be 51.8%. Patients with lepidic, acinar, and mucinous adenocarcinoma had 70.9%, 59.0%, and 66.6% 5-year survival, respectively, and there was no statistically significant difference between them. Whereas patients with solid, papillary, and micropapillary predominant adenocarcinoma had 41.0%, 40.5%, and 0.0% 5-year survival, respectively. Compared to other histologic subtypes, patients with solid and papillary predominant adenocarcinoma had significantly lower survival than those with lepidic (p<0.001, p=0.002), acinar (p<0.001, p=0.008), and mucinous (p=0.048, p=0.048) subtypes, respectively. The survival difference between patients with solid subtype and those with papillary subtype was not statistically significant (p=0.67). Conclusion: Solid and papillary histologic subtypes are poor prognostic factors in resected invasive lung adenocarcinoma. © 2019 by Trakya University Faculty of Medicine / The Balkan Medical Journal published by Galenos Publishing House.
dc.identifier.DOI-ID10.4274/balkanmedj.galenos.2019.2019.1.130
dc.identifier.issn21463123
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14301
dc.language.isoEnglish
dc.publisherGalenos Publishing House
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdenocarcinoma of Lung
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHistology
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectRetrospective Studies
dc.subjectacinar predominant lung adenocarcinoma
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbilobectomy
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectelectronic medical record
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectlepidic predominant lung adenocarcinoma
dc.subjectlung adenocarcinoma
dc.subjectlung lobectomy
dc.subjectlung resection
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicropapillary subtype lung adenocarcinoma
dc.subjectmucinous lung adenocarcinoma
dc.subjectoverall survival
dc.subjectpapillary predominant lung adenocarcinoma
dc.subjectpostoperative period
dc.subjectpredictive value
dc.subjectretrospective study
dc.subjectsolid predominant lung adenocarcinoma
dc.subjectsublobar resection
dc.subjectclassification
dc.subjectcross-sectional study
dc.subjecthistology
dc.subjectlung adenocarcinoma
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectprognosis
dc.subjectprospective study
dc.subjectvery elderly
dc.titlePrognostic effects of predominant histologic subtypes in resected pulmonary adenocarcinomas
dc.typeArticle

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